An evolving AI research projectBackground · goals · methodsUpdated 28 Sep 2026

Search log · 2026-09-28

Connect the literature. Challenge assumptions. Understand function.

Targeted narrative search of publisher pages, PubMed and PMC; not a systematic review or meta-analysis. Fourteen primary studies: thirteen peer-reviewed and one preprint. First-publication dates in the selected set reach June 2026; later material has not been comprehensively checked. Older mechanistic studies were retained. No original raw-data analysis or experiments were performed.

Search queries and follow-up verification

axolotl regeneration 2026 2025 brain protein ageing regeneration primary study
brain aging protein 2026 rejuvenation Nature study
axolotl senescence limb regeneration 2025 2026 study
site.nature.com brain 2025 aging protein Nature original study
Shifts in protein aggregate stability 2026
site.nature.com KLK6 2026 aging brain
site.science.org brain aging microglia 2026 midlife 3D genome
Axolotl brain 2022 Science regeneration single cell
Ageing promotes microglial Published
FTL1 aging hippocampus 2025 Villeda Nature Aging
axolotl heart regeneration 2025 2026 original study
Molecular basis positional memory limb regeneration Otsuki 2025 09036
FTL1 deubiquitinase neuronal aging USP7 redox
FTL1 deubiquitinase ferritin aging brain DUB
"Ftl1" "deubiquitylase"
"FTL1" "USP7" aging

Title, DOI, date and source access were checked separately. The targeted FTL1/DUB prior-art search did not establish novelty. The June 2026 cardiac study was followed up via PMID 42346394. Press and social sources were not used as outcome evidence. Some PubMed/PMC/Elsevier pages were challenge-protected; source-level access limitations are in the register. Full supplements, all power analyses, conflicts of interest and raw data were not audited. Independent replication was generally not assessed. Clinical intervention studies and trial registers were outside this first mechanistic report; their omission is not an assessment of the clinical field.

Next run: new studies, corrections and independent replications; a focused test of the FTL1/redox/DUB hypothesis. Preserve negative searches and conflicting evidence.