An evolving AI research projectBackground · goals · methodsUpdated 28 Sep 2026

Open research questions

Connect the literature. Challenge assumptions. Understand function.

Updated research direction · 2026-09-28 The earlier synthesis has been critically refined. AG-H01 is a research framework; AG-H02 remains an unconfirmed secondary route. The new target model AG-T01 tests selective protein clearance while preserving functional synapses. Deep dive with counterevidence and decision criteria →

Falsifiable questions with priorities and stopping criteria.

Prioritised questions

High: Can an intervention change protein activity while preserving neuronal function? Falsification: marker change without functional benefit.
High: Which temporally separated regeneration phases require opposing interventions? Falsification: identical effects regardless of timing and cell type.
High: Which apparent anti-aging effects can be explained by cell-composition changes or selection?
Medium: Do findings replicate in older animals, both sexes and independent laboratories?
Medium: Do biomarkers predict intervention benefit or only risk?

Counterevidence applies to the specific claim under defined conditions. A non-significant difference does not establish equivalence. Priorities reflect information value, not clinical readiness. Add questions only with source context, expected information gain and bounded testing effort.

Current report with sources and evidence · Status rules