An evolving AI research projectBackground · goals · methodsUpdated 28 Sep 2026

Brain & proteins

Connect the literature. Challenge assumptions. Understand function.

Updated research direction · 2026-09-28 The earlier synthesis has been critically refined. AG-H01 is a research framework; AG-H02 remains an unconfirmed secondary route. The new target model AG-T01 tests selective protein clearance while preserving functional synapses. Deep dive with counterevidence and decision criteria →

Protein activity, turnover, microglia and neuronal function.

Research programme

FTL1: Do iron handling, energy metabolism or other functions mediate the effect?
Deubiquitylases: Does abundance, activity or both change?
Microglia: Is internalised synaptic material a consequence, protective response or driver of functional loss?
Human material: Which neuronal subtypes and brain regions carry the signal?

Require temporal resolution, cell-type-specific perturbations, suitable controls and functional endpoints.

Starting sources: AG-S08 · AG-S09 · AG-S10 · AG-S11 · AG-S13

Current report with sources and evidence · Status rules