Aging/Study register
Addition dated 2026-09-28
AG-R01
Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice
Hemmer BM; Philippi SM et al. · Nature Communications · 2026-08-12 · DOI 10.1038/s41467-026-74906-z
Model / design: Mouse; genetic loss of function and supplementation; original research.
Evidence: mechanistic intervention; moderate, preclinical.
Access / limitations: publisher full text · Opposing substrate directions in Results; see bilingual dossier. Not silently corrected.
AG-R02
Ageing promotes microglial accumulation of slow-degrading synaptic proteins
Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9
Model / design: Mouse; neuron-specific protein tracing; original research.
Evidence: mechanistic tracing; moderate, preclinical.
Access / limitations: publisher full text
AG-R03
Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment
Jara C et al. · npj Aging · 2026-03-05 · DOI 10.1038/s41514-026-00351-3
Model / design: C57BL/6 and SAMP8 mice; original research.
Evidence: intervention; moderate within model, timing comparison confounded.
Access / limitations: publisher full text
AG-R04
The mitochondrial unfolded protein response in human microglia disrupts neuronal–glial communication and promotes senescence
Perez J MJ et al. · Nature Neuroscience · 2026-06-26 · DOI 10.1038/s41593-026-02320-1
Model / design: Human cellular models; induced mitochondrial stress; original research.
Evidence: mechanistic intervention; moderate in vitro, low aging translation.
Access / limitations: publisher full text
AG-R05
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
Castellano JM et al. · Nature · 2017-04-19 · DOI 10.1038/nature22067
Model / design: Aged mouse; original research.
Evidence: preclinical intervention; access-limited appraisal here.
Access / limitations: publisher abstract and bibliographic metadata
AG-R06
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains
Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y
Model / design: Vertebrate brain and cellular models; original research.
Evidence: mechanistic intervention; moderate, preclinical.
Access / limitations: publisher full text
AG-R07
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z
Model / design: Mouse and cellular models; original research.
Evidence: mechanistic intervention; moderate, preclinical.
Access / limitations: publisher full text
AG-R08
Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging
Britton R et al. · eNeuro · 2023-06-15 · DOI 10.1523/ENEURO.0031-23.2023
Model / design: Aged male C57BL/6J mice; original research.
Evidence: preclinical intervention; partial-access appraisal.
Access / limitations: PubMed abstract/figure captions and indexed publisher excerpts; publisher open returned 403; PMC returned CAPTCHA
Study register
DOI, date, model, design, evidence and peer review.
Publication date means first online publication, or the stated preprint version. Strength refers to the specified claim scope; all literature findings are ⚪ project level 1. “Not assessed” means neither confirmation nor refutation.
AG-S01
Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration
Yu Q et al. · Developmental Cell · 2023-10-24 · DOI 10.1016/j.devcel.2023.09.009
Model / design: Axolotl limb; Gain/loss of function.
Evidence: moderate, preclinical mechanism. Peer reviewed: yes.
Independent replication: not assessed. Access: Primary abstract and article metadata.
AG-S02
Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration
Wei X et al. · Science · 2022-09-02 · DOI 10.1126/science.abp9444
Model / design: Axolotl telencephalon; Spatial single-cell transcriptomics.
Evidence: moderate, descriptive animal atlas. Peer reviewed: yes.
Independent replication: not assessed. Access: Primary abstract and article metadata.
AG-S03
Molecular basis of positional memory in limb regeneration
Otsuki L et al. · Nature · 2025-05-21 · DOI 10.1038/s41586-025-09036-5
Model / design: Axolotl limb; Lineage analysis and signalling perturbation.
Evidence: moderate, preclinical mechanism. Peer reviewed: yes.
Independent replication: not assessed. Access: Publisher full text and primary abstract.
AG-S04
Adrenergic signaling coordinates distant and local responses to amputation in axolotl
Payzin-Dogru D et al. · Cell · 2025-10-24 · DOI 10.1016/j.cell.2025.09.025
Model / design: Axolotl amputation; Systemic and local signalling perturbation.
Evidence: moderate, preclinical mechanism. Peer reviewed: yes.
Independent replication: not assessed. Access: Publisher summary; PMC publication metadata.
AG-S05
Neuronal activation in the axolotl brain promotes tail regeneration
Walker SE et al. · npj Regenerative Medicine · 2025-05-08 · DOI 10.1038/s41536-025-00413-2
Model / design: Axolotl brain and tail; Neural mapping and pharmacological perturbation.
Evidence: moderate, preclinical mechanism. Peer reviewed: yes.
Independent replication: not assessed. Access: Publisher full text.
AG-S06
Metabolic changes during cardiac regeneration in the axolotl
Dittrich A et al. · Developmental Dynamics · 2025-03-22 · DOI 10.1002/dvdy.70020
Model / design: Axolotl cardiac cryoinjury; Metabolic profiling and oxygen intervention.
Evidence: limited-to-moderate, exploratory animal study. Peer reviewed: yes.
Independent replication: not assessed. Access: Publisher metadata and PMC indexed full text.
AG-S07
A characterization of axolotl digit regeneration: conserved mechanisms, divergent patterning, and a critical role for hedgehog signaling
Griffiths JR et al. · npj Regenerative Medicine · 2026-03-25 · DOI 10.1038/s41536-026-00461-2
Model / design: Juvenile axolotl digits; Anatomical comparison and hedgehog perturbation.
Evidence: moderate, endpoint- and anatomy-specific animal evidence. Peer reviewed: yes.
Independent replication: not assessed. Access: Publisher full text.
AG-S08
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains
Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y
Model / design: Mouse, killifish, human iPSC-derived neurons; Activity-based proteomics and perturbation.
Evidence: moderate, multi-model preclinical mechanism. Peer reviewed: yes.
Independent replication: Multiple cohorts/models within one paper; external replication not assessed. Access: Publisher full text.
AG-S09
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z
Model / design: Mouse hippocampus and primary neurons; Viral/genetic manipulation and behavioural readouts.
Evidence: moderate, preclinical intervention. Peer reviewed: yes.
Independent replication: not assessed. Access: Publisher full text.
AG-S10
Ageing promotes microglial accumulation of slow-degrading synaptic proteins
Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9
Model / design: Mouse neuronal proteome; complementary human material; Cell-specific pulse-chase proteomics and microglial analysis.
Evidence: moderate, descriptive/longitudinal protein-tracing animal evidence. Peer reviewed: yes.
Independent replication: not assessed. Access: Publisher full text.
AG-S11
Single-cell transcriptomic and genomic changes in the ageing human brain
Jeffries AM et al. · Nature · 2025-09-03 · DOI 10.1038/s41586-025-09435-8
Model / design: Human post-mortem prefrontal cortex; snRNA-seq, single-cell genome sequencing, spatial validation.
Evidence: moderate, cross-sectional human observation. Peer reviewed: yes.
Independent replication: Within-paper orthogonal validation; external replication not assessed. Access: Publisher full text.
AG-S12
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
Wang Y et al. · Nature Aging · 2025-11-26 · DOI 10.1038/s43587-025-01016-8
Model / design: UK, Chinese and US human cohorts; Observational plasma proteomics with external cohort validation.
Evidence: moderate-to-strong for prediction; not causal or interventional. Peer reviewed: yes.
Independent replication: External cohorts within one publication; distinct external team not established. Access: Publisher full text.
AG-S13
Shifts in protein aggregate stability define proteostasis decline in the aging human brain
Anderton E et al. · bioRxiv · 2026-04-18 · DOI 10.64898/2026.03.27.714902
Model / design: Human post-mortem hippocampus; Detergent-fractionation proteomics.
Evidence: low, unreviewed human observation. Peer reviewed: NO – preprint.
Independent replication: not established. Access: Version-2 indexed abstract; version-1 primary full text; version-2 metadata.
AG-S14
Temperature-Dependent Modulation of Cardiac Metabolism, Post-Injury Survival and Regenerative Rate in Axolotls
Dittrich A et al. · Metabolites · 2026-06-13 · DOI 10.3390/metabo16060414
Model / design: Adult axolotl cardiac cryoinjury; Temperature intervention; imaging, physiology and histology.
Evidence: limited-to-moderate, small preclinical groups. Peer reviewed: yes.
Independent replication: Not assessed; author overlap with AG-S06. Access: PMC primary full text and PubMed publication metadata.
Current report with sources and evidence · Status rules
Altern / Aging research world · Updated 2026-09-28. No self-medication or personal treatment plans.