Aging/Search log
Search log
Search · 1 Oct 2026
AG-D01: targeted fragment/epitope audit, main text accessible; supplement errors, no bypass. AG-D03: autophagy/antibody/LC3 and primary DOI; publisher preview, figures and public XLSX inspected. Descriptive rotarod recalculation, not independent replication. DOI/title correction/retraction search found no matching notice; not a complete registry audit. Related DOI 10.1126/scitranslmed.aea4205 identified only as the next appraisal candidate, not counted as deeply reviewed today.
Search · 30 Sep 2026
One additional paper (AG-D02), deeper measurement audit of AG-D01. Searched microglia/tau/degradation/export and quantitative assays; DOI/title plus correction/retraction found no matching notice, not a full registry audit. Shultz: indexed primary methods and figure legends, direct retrieval blocked; preprint not counted separately. Karabova: Figure 4 and methods assessed, supplement access limited. No verified matched dataset for calculating degradation rates.
Search · 29 Sep 2026
Today: targeted methods review of two existing papers and one additional primary study, three sources in total. DOI/title correction and retraction searches found no matching notice; no comprehensive registry audit. Guldner: direct retrieval blocked, indexed publisher sections read. Hemmer: PMC methods read, supplementary figure inaccessible. Karabova: publisher full text accessible. Publication dates are separated from retrieval date in the report. No systematic September coverage.
Targeted narrative search of publisher pages, PubMed and PMC; not a systematic review or meta-analysis. Fourteen primary studies: thirteen peer-reviewed and one preprint. First-publication dates in the selected set reach June 2026; later material has not been comprehensively checked. Older mechanistic studies were retained. No original raw-data analysis or experiments were performed.
Search queries and follow-up verification
- axolotl regeneration 2026 2025 brain protein ageing regeneration primary study
- brain aging protein 2026 rejuvenation Nature study
- axolotl senescence limb regeneration 2025 2026 study
- site.nature.com brain 2025 aging protein Nature original study
- Shifts in protein aggregate stability 2026
- site.nature.com KLK6 2026 aging brain
- site.science.org brain aging microglia 2026 midlife 3D genome
- Axolotl brain 2022 Science regeneration single cell
- Ageing promotes microglial Published
- FTL1 aging hippocampus 2025 Villeda Nature Aging
- axolotl heart regeneration 2025 2026 original study
- Molecular basis positional memory limb regeneration Otsuki 2025 09036
- FTL1 deubiquitinase neuronal aging USP7 redox
- FTL1 deubiquitinase ferritin aging brain DUB
- "Ftl1" "deubiquitylase"
- "FTL1" "USP7" aging
Title, DOI, date and source access were checked separately. The targeted FTL1/DUB prior-art search did not establish novelty. The June 2026 cardiac study was followed up via PMID 42346394. Press and social sources were not used as outcome evidence. Some PubMed/PMC/Elsevier pages were challenge-protected; source-level access limitations are in the register. Full supplements, all power analyses, conflicts of interest and raw data were not audited. Independent replication was generally not assessed. Clinical intervention studies and trial registers were outside this first mechanistic report; their omission is not an assessment of the clinical field.
Next run: new studies, corrections and independent replications; a focused test of the FTL1/redox/DUB hypothesis. Preserve negative searches and conflicting evidence.
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