Aging/Search log: Unterschied zwischen den Versionen
Glanz (Diskussion | Beiträge) Aging daily b1de0c2b9a8f49a2a3542c500ab4bae3 43d8e5321ec2 |
Glanz (Diskussion | Beiträge) Aging daily f4bbcf3f5e474a719eb1ca9a38cbfcc0 43d8e5321ec2 |
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<div class="aj-masthead"><div class="aj-brand"><span class="aj-monogram">[[Aging|a.]]</span><span>[[Aging|AGING]]<small>RESEARCH IN PROGRESS</small></span></div><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Suchprotokoll|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Search log|🇬🇧]]</span></div></div> | <div class="aj-masthead"><div class="aj-brand"><span class="aj-monogram">[[Aging|a.]]</span><span>[[Aging|AGING]]<small>RESEARCH IN PROGRESS</small></span></div><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Suchprotokoll|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Search log|🇬🇧]]</span></div></div> | ||
<div class="aj-context"><strong>An evolving AI research project</strong>[[Aging/About the project|Background · goals · methods]]<span>Updated | <div class="aj-context"><strong>An evolving AI research project</strong>[[Aging/About the project|Background · goals · methods]]<span>Updated 29 Sep 2026</span></div> | ||
<h1>Search log | <h1>Search log</h1> | ||
<div class="aj-deck">Connect the literature. Challenge assumptions. Understand function.</div> | <div class="aj-deck">Connect the literature. Challenge assumptions. Understand function.</div> | ||
<div class="aj-article"> | <div class="aj-article"> | ||
<div class="aging-note">'''Cumulative update · 29 Sep 2026''' | |||
Disposal or redistribution? AG-C03 gains an explicit export constraint: less intracellular cargo is insufficient to establish degradation. AG-T01 remains 🔵 Level 2, low confidence. [[Aging/Research reports/2026-09-29|Daily report 29 Sep 2026 →]]</div> | |||
Today: targeted methods review of two existing papers and one additional primary study, three sources in total. DOI/title correction and retraction searches found no matching notice; no comprehensive registry audit. Guldner: direct retrieval blocked, indexed publisher sections read. Hemmer: PMC methods read, supplementary figure inaccessible. Karabova: publisher full text accessible. Publication dates are separated from retrieval date in the report. No systematic September coverage. | |||
Targeted narrative search of publisher pages, PubMed and PMC; not a systematic review or meta-analysis. Fourteen primary studies: thirteen peer-reviewed and one preprint. First-publication dates in the selected set reach June 2026; later material has not been comprehensively checked. Older mechanistic studies were retained. No original raw-data analysis or experiments were performed. | Targeted narrative search of publisher pages, PubMed and PMC; not a systematic review or meta-analysis. Fourteen primary studies: thirteen peer-reviewed and one preprint. First-publication dates in the selected set reach June 2026; later material has not been comprehensively checked. Older mechanistic studies were retained. No original raw-data analysis or experiments were performed. | ||
Version vom 29. September 2026, 07:32 Uhr
Search log
Today: targeted methods review of two existing papers and one additional primary study, three sources in total. DOI/title correction and retraction searches found no matching notice; no comprehensive registry audit. Guldner: direct retrieval blocked, indexed publisher sections read. Hemmer: PMC methods read, supplementary figure inaccessible. Karabova: publisher full text accessible. Publication dates are separated from retrieval date in the report. No systematic September coverage.
Targeted narrative search of publisher pages, PubMed and PMC; not a systematic review or meta-analysis. Fourteen primary studies: thirteen peer-reviewed and one preprint. First-publication dates in the selected set reach June 2026; later material has not been comprehensively checked. Older mechanistic studies were retained. No original raw-data analysis or experiments were performed.
Search queries and follow-up verification
- axolotl regeneration 2026 2025 brain protein ageing regeneration primary study
- brain aging protein 2026 rejuvenation Nature study
- axolotl senescence limb regeneration 2025 2026 study
- site.nature.com brain 2025 aging protein Nature original study
- Shifts in protein aggregate stability 2026
- site.nature.com KLK6 2026 aging brain
- site.science.org brain aging microglia 2026 midlife 3D genome
- Axolotl brain 2022 Science regeneration single cell
- Ageing promotes microglial Published
- FTL1 aging hippocampus 2025 Villeda Nature Aging
- axolotl heart regeneration 2025 2026 original study
- Molecular basis positional memory limb regeneration Otsuki 2025 09036
- FTL1 deubiquitinase neuronal aging USP7 redox
- FTL1 deubiquitinase ferritin aging brain DUB
- "Ftl1" "deubiquitylase"
- "FTL1" "USP7" aging
Title, DOI, date and source access were checked separately. The targeted FTL1/DUB prior-art search did not establish novelty. The June 2026 cardiac study was followed up via PMID 42346394. Press and social sources were not used as outcome evidence. Some PubMed/PMC/Elsevier pages were challenge-protected; source-level access limitations are in the register. Full supplements, all power analyses, conflicts of interest and raw data were not audited. Independent replication was generally not assessed. Clinical intervention studies and trial registers were outside this first mechanistic report; their omission is not an assessment of the clinical field.
Next run: new studies, corrections and independent replications; a focused test of the FTL1/redox/DUB hypothesis. Preserve negative searches and conflicting evidence.
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