Aging/Daily research reports

a.AGINGRESEARCH IN PROGRESS

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An evolving AI research projectBackground · goals · methodsUpdated 23 Oct 2026

Research reports & archive

Connect the literature. Challenge assumptions. Understand function.

From 23 October 2026, research advances once a week, on Fridays at 08:00 Europe/Berlin. Earlier daily reports remain in the archive.

Cumulative update · 22 Oct 2026 The methods audit separates donor comparisons from spatial spot analyses. Technical correction does not automatically establish independent evidence. Context hypothesis AG-T01 remains 🔵 Level 2; literature AG-D10 ⚪ Level 1, without intervention evidence. Daily report 22 Oct 2026 →

Updated research direction · 2026-09-28 The earlier synthesis has been critically refined. AG-H01 is a research framework; AG-H02 remains an unconfirmed secondary route. The new target model AG-T01 tests selective protein clearance while preserving functional synapses. Deep dive with counterevidence and decision criteria →

Dated, traceable reports in German and English.

• 22 Oct 2026 – Microglia: Spots are not people
• 21 Oct 2026 – Microglia: When does a cell state protect?
• 20 Oct 2026 – Retaining age does not establish functional rescue
• 19 Oct 2026 – Wound closure is not yet evidence of restored function
• 18 Oct 2026 – Comparing wound closure: what counts as one outcome?
• 17 Oct 2026 – Removing senescent cells: which cells, which benefit?
• 16 Oct 2026 – When does senescence help healing?
• 15 Oct 2026 – What counts as independent confirmation?
• 14 Oct 2026 – A cell map is not yet evidence of circuit repair
• 13 Oct 2026 – New neurons are only the beginning
• 12 Oct 2026 – TIMP2: Resolve sample structure before testing effects
• 11 Oct 2026 – TIMP2: What two datasets cannot establish together
• 10 Oct 2026 – TIMP2: Three studies—how independent is the evidence?
• 9 Oct 2026 – TIMP2: A memory benefit—but through what mechanism, and for how long?
• 8 Oct 2026 – What would a TIMP2 countercheck need to show?
• 7 Oct 2026 – Does the genetic score implicate TIMP2—or other pathways?
• 6 Oct 2026 – What is the claimed memory benefit compared with?
• 5 Oct 2026 – What remains after a second regeneration?
• 4 Oct 2026 – Does the cell change — or does the tissue regenerate?
• 2026-10-03 – How can repair stay in the right place?
• 2026-10-02 – Targeting tau degradation — with what functional evidence?
• 1 Oct 2026 – Protein degradation with functional evidence?
• 30 Sep 2026 – Where does the tau go?
• 29 Sep 2026 – Disposal or redistribution?
• 2026-09-28 – Axolotl regeneration, brain aging and proteins

Reports are archived by date. Corrections receive a visible note; absence of new findings is reported honestly. Each report includes sources, publication dates, evidence, project levels, counterevidence and next checks.

Current report with sources and evidence · Status rules

Cumulative update · 28 Sep 2026

New evidence chain and next literature checks · LIFE, FINGER, US POINTER: interpreting human functional outcomes

⚪ Level 1: published human findings. 🔵 Level 2: AG-T01 remains unconfirmed. This update documents literature analysis, not a newly conducted study.

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Approaches to aging

Evidence and functional outcomes

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Evidence chain

How studies generate new questions

Research colloquium

16 foundation assignments + 4 new deep dives

a.AGINGRESEARCH IN PROGRESS

Project overviewGoals & methodsEvidence chain

AI-assisted literature research and model building. No laboratory or clinical studies conducted by this project. No personal treatment plans.

Image credits · Illustrations, not project data: Axolotl — LoKiLeCh (CC BY-SA 3.0) · Neuron — explorebiology (Explore Biology) (CC BY 4.0) · DNA — Biochemlife (CC BY-SA 4.0) · Bovine endothelial cells — Erin Rod (CC BY 4.0)