Aging
Aging — an evolving AI research project
Clear harmful proteins. Preserve working synapses?
We connect published studies of TIMP2, microglia and protein turnover. We seek a mechanism that clears harmful cargo while preserving neuronal function. This connection remains an unconfirmed working hypothesis.
TIMP2 changes how microglia handle cargo
TIMP2 affected microglial states and cargo processing in mice. The study also includes a myelin clearance assay following genetic deletion.
Protein stock does not establish degradation flux
Neuronal labeling tracks slowly degraded proteins into microglia. For our model, the key issue is that increased stored cargo can have different causes.
Better markers do not establish memory recovery
Urolithin A improved molecular measurements in aged C57BL/6 mice without demonstrating recovery in the memory tests examined.
Ten entries distinguish human functional outcomes, preclinical candidates and hypotheses. LIFE, FINGER and US POINTER provide human benchmarks, without establishing a solution to biological aging.
Explore the list →Each new study should strengthen, constrain or change a specific claim. Independent evidence routes, counterevidence and missing links remain visible. This project conducts no experiments.
Follow the argument →16 foundation assignments and 4 new deep dives: challenge causal models, critically read published data and connect conflicting studies. Substantive new findings become dated addition packages with their own Wish-List entries.
Explore the research journal
Researchers explain the foundations
Institutional talks for context. These older videos are background material; current claims rely on the linked primary studies.
Axolotl regeneration
YouTube
Brain aging in its systemic context
YouTube
