Aging/Approaches to aging
An evolving AI research projectBackground · goals · methodsUpdated 28 Sep 2026
Approaches to aging
What may counter age-related functional decline · Updated 28 September 2026
This list grows with the evidence. Its first entries concern human function; subsequent entries are mechanistic candidates or untested hypotheses. Inclusion does not establish slowing of human aging. The order is not a personal treatment recommendation.
AG-A01 · Structured physical activity
Human function · Project level 1
- Outcome / target: Less major mobility disability than with health education.
- Population / model: Older adults at mobility risk.
- Evidence: Randomised; functional endpoint.
- Limits / counterevidence: Serious harms not excluded; no general aging reversal.
- Next desk check: Check adherence, safety and separate long-term replications.
- Sources: AG-J01 · 2014-05-27
AG-A02 · Combined programs for cognition
Human function · Project level 1
- Outcome / target: Small composite-test advantages over each study’s comparator.
- Population / model: People at elevated cognitive risk.
- Evidence: Two randomised cohorts; related programs.
- Limits / counterevidence: Components unresolved; dementia prevention unproven. Assess burdens.
- Next desk check: Check contact time, practice effects, daily relevance and counterstudies.
- Sources: AG-J02 · 2015-03-12; AG-J03 · 2025-07-28
AG-A03 · TIMP2 as a functional candidate
Preclinical · Project level 1
- Outcome / target: Target: plasticity with preserved connections.
- Population / model: Mouse.
- Evidence: Preclinical; mechanism unresolved.
- Limits / counterevidence: Direct neuronal action competes with microglial mediation.
- Next desk check: Examine discrepancies and availability of comparative data.
- Sources: AG-R01 · 2026-08-12; AG-R05 · 2017-04-19; AG-R08 · 2023-06-15
AG-A04 · Targeted FTL1 regulation
Preclinical · Project level 1
- Outcome / target: Target: reliable neuronal function.
- Population / model: Mouse.
- Evidence: Mechanistic candidate.
- Limits / counterevidence: Avoid blanket iron suppression; transferability unresolved.
- Next desk check: Check cellular specificity, exposure and separate functional replication.
- Sources: AG-S09 · 2025-08-19
AG-A05 · Redox-dependent protein control
Preclinical · Project level 1
- Outcome / target: Target: function after selective DUB modulation.
- Population / model: Vertebrate models.
- Evidence: Mechanistic candidate.
- Limits / counterevidence: Enzyme activity does not establish cognition; broad interventions ambiguous.
- Next desk check: Seek selective mediation and functional counterevidence.
- Sources: AG-S08 · 2026-04-21
AG-A06 · Mitochondrial quality control
Preclinical · Project level 1
- Outcome / target: Target: actual restoration beyond favourable markers.
- Population / model: Mouse.
- Evidence: Limited; functional findings differ.
- Limits / counterevidence: Do not equate prevention with reversal.
- Next desk check: Prioritise age- and strain-matched comparisons.
- Sources: AG-R03 · 2026-03-05
AG-A07 · Spatial control of regeneration
Preclinical · Project level 1
- Outcome / target: Target: correct reconnection following repair.
- Population / model: Axolotl; injury.
- Evidence: Comparative regeneration biology.
- Limits / counterevidence: Tissue regrowth does not establish human aging benefit.
- Next desk check: Check conserved mechanisms and transfer limits.
- Sources: AG-S03 · 2025-05-21
AG-A08 · Understand senescence over time
Preclinical · Project level 1
- Outcome / target: Target: repair without chronic functional harm.
- Population / model: Axolotl; regeneration.
- Evidence: Context-dependent mechanistic candidate.
- Limits / counterevidence: No basis for indiscriminate cell removal.
- Next desk check: Compare timing, cell type and state resolution.
- Sources: AG-S01 · 2023-10-24
AG-A09 · AG-T01: selective cargo degradation
Hypothesis · Project level 2
- Outcome / target: Hypothesis: jointly improve degradation, synapse preservation and function.
- Population / model: Proposed aged neuronal system.
- Evidence: Untested project synthesis.
- Limits / counterevidence: Partial mediation and cargo selectivity unconfirmed.
- Next desk check: Develop preregistrable balance measurements and alternative models.
- Sources: AG-R01 · 2026-08-12; AG-R02 · 2026-01-21; AG-R08 · 2023-06-15
AG-A10 · AG-H02: FTL1–redox–DUB
Hypothesis · Project level 2
- Outcome / target: Hypothesis: a causal mediation chain.
- Population / model: No joint test.
- Evidence: Low priority; untested.
- Limits / counterevidence: Separate findings do not establish the chain.
- Next desk check: First check direct prior evidence and counterevidence.
- Sources: AG-S08 · 2026-04-21; AG-S09 · 2025-08-19
Updating: New approaches require a verifiable source or explicit hypothesis basis, a functional target endpoint, model limits and the next decisive countercheck. Failed or narrowed approaches remain visible with reasons. Category, evidence and project level are updated separately.
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