Aging/Brain & proteins
Updated research direction · 2026-09-28
The earlier synthesis has been critically refined. AG-H01 is a research framework; AG-H02 remains an unconfirmed secondary route. The new target model AG-T01 tests selective protein clearance while preserving functional synapses. Deep dive with counterevidence and decision criteria →
Brain & proteins
Protein activity, turnover, microglia and neuronal function.
Research programme
- FTL1: Do iron handling, energy metabolism or other functions mediate the effect?
- Deubiquitylases: Does abundance, activity or both change?
- Microglia: Is internalised synaptic material a consequence, protective response or driver of functional loss?
- Human material: Which neuronal subtypes and brain regions carry the signal?
Require temporal resolution, cell-type-specific perturbations, suitable controls and functional endpoints.
Starting sources: AG-S08 · AG-S09 · AG-S10 · AG-S11 · AG-S13
Current report with sources and evidence · Status rules
Altern / Aging research world · Updated 2026-09-28. No self-medication or personal treatment plans.