Altern/Studienübersicht
Studienübersicht
DOI, Datum, Modell, Design, Evidenz und Peer-Review.
Publikationsdatum bezeichnet das erste Online-Datum, beim Preprint die ausgewiesene Fassung. Stärke bezieht sich auf den jeweiligen Aussagebereich; sämtliche Literaturbefunde sind ⚪ Projektstufe 1. „Nicht beurteilt“ ist keine Bestätigung und keine Widerlegung.
AG-S01
Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration
Yu Q et al. · Developmental Cell · 2023-10-24 · DOI 10.1016/j.devcel.2023.09.009
Modell / Design: Axolotl limb; Gain/loss of function.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Primary abstract and article metadata.
AG-S02
Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration
Wei X et al. · Science · 2022-09-02 · DOI 10.1126/science.abp9444
Modell / Design: Axolotl telencephalon; Spatial single-cell transcriptomics.
Evidenz: moderate, descriptive animal atlas. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Primary abstract and article metadata.
AG-S03
Molecular basis of positional memory in limb regeneration
Otsuki L et al. · Nature · 2025-05-21 · DOI 10.1038/s41586-025-09036-5
Modell / Design: Axolotl limb; Lineage analysis and signalling perturbation.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text and primary abstract.
AG-S04
Adrenergic signaling coordinates distant and local responses to amputation in axolotl
Payzin-Dogru D et al. · Cell · 2025-10-24 · DOI 10.1016/j.cell.2025.09.025
Modell / Design: Axolotl amputation; Systemic and local signalling perturbation.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher summary; PMC publication metadata.
AG-S05
Neuronal activation in the axolotl brain promotes tail regeneration
Walker SE et al. · npj Regenerative Medicine · 2025-05-08 · DOI 10.1038/s41536-025-00413-2
Modell / Design: Axolotl brain and tail; Neural mapping and pharmacological perturbation.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S06
Metabolic changes during cardiac regeneration in the axolotl
Dittrich A et al. · Developmental Dynamics · 2025-03-22 · DOI 10.1002/dvdy.70020
Modell / Design: Axolotl cardiac cryoinjury; Metabolic profiling and oxygen intervention.
Evidenz: limited-to-moderate, exploratory animal study. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher metadata and PMC indexed full text.
AG-S07
A characterization of axolotl digit regeneration: conserved mechanisms, divergent patterning, and a critical role for hedgehog signaling
Griffiths JR et al. · npj Regenerative Medicine · 2026-03-25 · DOI 10.1038/s41536-026-00461-2
Modell / Design: Juvenile axolotl digits; Anatomical comparison and hedgehog perturbation.
Evidenz: moderate, endpoint- and anatomy-specific animal evidence. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S08
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains
Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y
Modell / Design: Mouse, killifish, human iPSC-derived neurons; Activity-based proteomics and perturbation.
Evidenz: moderate, multi-model preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: Multiple cohorts/models within one paper; external replication not assessed. Zugriff: Publisher full text.
AG-S09
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z
Modell / Design: Mouse hippocampus and primary neurons; Viral/genetic manipulation and behavioural readouts.
Evidenz: moderate, preclinical intervention. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S10
Ageing promotes microglial accumulation of slow-degrading synaptic proteins
Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9
Modell / Design: Mouse neuronal proteome; complementary human material; Cell-specific pulse-chase proteomics and microglial analysis.
Evidenz: moderate, descriptive/longitudinal protein-tracing animal evidence. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S11
Single-cell transcriptomic and genomic changes in the ageing human brain
Jeffries AM et al. · Nature · 2025-09-03 · DOI 10.1038/s41586-025-09435-8
Modell / Design: Human post-mortem prefrontal cortex; snRNA-seq, single-cell genome sequencing, spatial validation.
Evidenz: moderate, cross-sectional human observation. Begutachtet: ja.
Unabhängige Reproduktion: Within-paper orthogonal validation; external replication not assessed. Zugriff: Publisher full text.
AG-S12
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
Wang Y et al. · Nature Aging · 2025-11-26 · DOI 10.1038/s43587-025-01016-8
Modell / Design: UK, Chinese and US human cohorts; Observational plasma proteomics with external cohort validation.
Evidenz: moderate-to-strong for prediction; not causal or interventional. Begutachtet: ja.
Unabhängige Reproduktion: External cohorts within one publication; distinct external team not established. Zugriff: Publisher full text.
AG-S13
Shifts in protein aggregate stability define proteostasis decline in the aging human brain
Anderton E et al. · bioRxiv · 2026-04-18 · DOI 10.64898/2026.03.27.714902
Modell / Design: Human post-mortem hippocampus; Detergent-fractionation proteomics.
Evidenz: low, unreviewed human observation. Begutachtet: NEIN – Preprint.
Unabhängige Reproduktion: not established. Zugriff: Version-2 indexed abstract; version-1 primary full text; version-2 metadata.
AG-S14
Temperature-Dependent Modulation of Cardiac Metabolism, Post-Injury Survival and Regenerative Rate in Axolotls
Dittrich A et al. · Metabolites · 2026-06-13 · DOI 10.3390/metabo16060414
Modell / Design: Adult axolotl cardiac cryoinjury; Temperature intervention; imaging, physiology and histology.
Evidenz: limited-to-moderate, small preclinical groups. Begutachtet: ja.
Unabhängige Reproduktion: Not assessed; author overlap with AG-S06. Zugriff: PMC primary full text and PubMed publication metadata.
Aktueller Bericht mit Quellen und Evidenz · Statusregeln
Forschungswelt Altern / Aging · Stand 28.09.2026. Keine Selbstmedikation oder persönlichen Therapiepläne.