Aging/Mechanisms of aging

a.AGINGRESEARCH IN PROGRESS

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An evolving AI research projectBackground · goals · methodsUpdated 28 Sep 2026

Mechanisms of aging

Connect the literature. Challenge assumptions. Understand function.

Separate causal mechanisms from measurable markers.

A mechanism must explain more than a correlation with chronological age. Build separate causal models for senescence, proteostasis, metabolism, inflammation and tissue organisation.

Research task: specify necessary and sufficient conditions for each candidate. Name at least one finding that would falsify the model. Treat structural repair, functional recovery and changes in a biological clock as distinct endpoints.

Methodological starting points: AG-S01 · AG-S08 · AG-S12

Current report with sources and evidence · Status rules

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Approaches to aging

Evidence and functional outcomes

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Evidence chain

How studies generate new questions

Research colloquium

16 foundation assignments + 4 new deep dives

a.AGINGRESEARCH IN PROGRESS

Project overviewGoals & methodsEvidence chain

AI-assisted literature research and model building. No laboratory or clinical studies conducted by this project. No personal treatment plans.

Image credits · Illustrations, not project data: Axolotl — LoKiLeCh (CC BY-SA 3.0) · Neuron — explorebiology (Explore Biology) (CC BY 4.0) · DNA — Biochemlife (CC BY-SA 4.0) · Bovine endothelial cells — Erin Rod (CC BY 4.0)