Altern/Studienübersicht
Ergänzung vom 28.09.2026
AG-R01
Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice
Hemmer BM; Philippi SM et al. · Nature Communications · 2026-08-12 · DOI 10.1038/s41467-026-74906-z
Modell / Design: Mouse; genetic loss of function and supplementation; original research.
Evidenz: mechanistic intervention; moderate, preclinical.
Zugriff / Grenzen: publisher full text · Opposing substrate directions in Results; see bilingual dossier. Not silently corrected.
AG-R02
Ageing promotes microglial accumulation of slow-degrading synaptic proteins
Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9
Modell / Design: Mouse; neuron-specific protein tracing; original research.
Evidenz: mechanistic tracing; moderate, preclinical.
Zugriff / Grenzen: publisher full text
AG-R03
Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment
Jara C et al. · npj Aging · 2026-03-05 · DOI 10.1038/s41514-026-00351-3
Modell / Design: C57BL/6 and SAMP8 mice; original research.
Evidenz: intervention; moderate within model, timing comparison confounded.
Zugriff / Grenzen: publisher full text
AG-R04
The mitochondrial unfolded protein response in human microglia disrupts neuronal–glial communication and promotes senescence
Perez J MJ et al. · Nature Neuroscience · 2026-06-26 · DOI 10.1038/s41593-026-02320-1
Modell / Design: Human cellular models; induced mitochondrial stress; original research.
Evidenz: mechanistic intervention; moderate in vitro, low aging translation.
Zugriff / Grenzen: publisher full text
AG-R05
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
Castellano JM et al. · Nature · 2017-04-19 · DOI 10.1038/nature22067
Modell / Design: Aged mouse; original research.
Evidenz: preclinical intervention; access-limited appraisal here.
Zugriff / Grenzen: publisher abstract and bibliographic metadata
AG-R06
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains
Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y
Modell / Design: Vertebrate brain and cellular models; original research.
Evidenz: mechanistic intervention; moderate, preclinical.
Zugriff / Grenzen: publisher full text
AG-R07
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z
Modell / Design: Mouse and cellular models; original research.
Evidenz: mechanistic intervention; moderate, preclinical.
Zugriff / Grenzen: publisher full text
AG-R08
Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging
Britton R et al. · eNeuro · 2023-06-15 · DOI 10.1523/ENEURO.0031-23.2023
Modell / Design: Aged male C57BL/6J mice; original research.
Evidenz: preclinical intervention; partial-access appraisal.
Zugriff / Grenzen: PubMed abstract/figure captions and indexed publisher excerpts; publisher open returned 403; PMC returned CAPTCHA
Studienübersicht
DOI, Datum, Modell, Design, Evidenz und Peer-Review.
Publikationsdatum bezeichnet das erste Online-Datum, beim Preprint die ausgewiesene Fassung. Stärke bezieht sich auf den jeweiligen Aussagebereich; sämtliche Literaturbefunde sind ⚪ Projektstufe 1. „Nicht beurteilt“ ist keine Bestätigung und keine Widerlegung.
AG-S01
Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration
Yu Q et al. · Developmental Cell · 2023-10-24 · DOI 10.1016/j.devcel.2023.09.009
Modell / Design: Axolotl limb; Gain/loss of function.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Primary abstract and article metadata.
AG-S02
Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration
Wei X et al. · Science · 2022-09-02 · DOI 10.1126/science.abp9444
Modell / Design: Axolotl telencephalon; Spatial single-cell transcriptomics.
Evidenz: moderate, descriptive animal atlas. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Primary abstract and article metadata.
AG-S03
Molecular basis of positional memory in limb regeneration
Otsuki L et al. · Nature · 2025-05-21 · DOI 10.1038/s41586-025-09036-5
Modell / Design: Axolotl limb; Lineage analysis and signalling perturbation.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text and primary abstract.
AG-S04
Adrenergic signaling coordinates distant and local responses to amputation in axolotl
Payzin-Dogru D et al. · Cell · 2025-10-24 · DOI 10.1016/j.cell.2025.09.025
Modell / Design: Axolotl amputation; Systemic and local signalling perturbation.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher summary; PMC publication metadata.
AG-S05
Neuronal activation in the axolotl brain promotes tail regeneration
Walker SE et al. · npj Regenerative Medicine · 2025-05-08 · DOI 10.1038/s41536-025-00413-2
Modell / Design: Axolotl brain and tail; Neural mapping and pharmacological perturbation.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S06
Metabolic changes during cardiac regeneration in the axolotl
Dittrich A et al. · Developmental Dynamics · 2025-03-22 · DOI 10.1002/dvdy.70020
Modell / Design: Axolotl cardiac cryoinjury; Metabolic profiling and oxygen intervention.
Evidenz: limited-to-moderate, exploratory animal study. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher metadata and PMC indexed full text.
AG-S07
A characterization of axolotl digit regeneration: conserved mechanisms, divergent patterning, and a critical role for hedgehog signaling
Griffiths JR et al. · npj Regenerative Medicine · 2026-03-25 · DOI 10.1038/s41536-026-00461-2
Modell / Design: Juvenile axolotl digits; Anatomical comparison and hedgehog perturbation.
Evidenz: moderate, endpoint- and anatomy-specific animal evidence. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S08
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains
Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y
Modell / Design: Mouse, killifish, human iPSC-derived neurons; Activity-based proteomics and perturbation.
Evidenz: moderate, multi-model preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: Multiple cohorts/models within one paper; external replication not assessed. Zugriff: Publisher full text.
AG-S09
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z
Modell / Design: Mouse hippocampus and primary neurons; Viral/genetic manipulation and behavioural readouts.
Evidenz: moderate, preclinical intervention. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S10
Ageing promotes microglial accumulation of slow-degrading synaptic proteins
Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9
Modell / Design: Mouse neuronal proteome; complementary human material; Cell-specific pulse-chase proteomics and microglial analysis.
Evidenz: moderate, descriptive/longitudinal protein-tracing animal evidence. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S11
Single-cell transcriptomic and genomic changes in the ageing human brain
Jeffries AM et al. · Nature · 2025-09-03 · DOI 10.1038/s41586-025-09435-8
Modell / Design: Human post-mortem prefrontal cortex; snRNA-seq, single-cell genome sequencing, spatial validation.
Evidenz: moderate, cross-sectional human observation. Begutachtet: ja.
Unabhängige Reproduktion: Within-paper orthogonal validation; external replication not assessed. Zugriff: Publisher full text.
AG-S12
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
Wang Y et al. · Nature Aging · 2025-11-26 · DOI 10.1038/s43587-025-01016-8
Modell / Design: UK, Chinese and US human cohorts; Observational plasma proteomics with external cohort validation.
Evidenz: moderate-to-strong for prediction; not causal or interventional. Begutachtet: ja.
Unabhängige Reproduktion: External cohorts within one publication; distinct external team not established. Zugriff: Publisher full text.
AG-S13
Shifts in protein aggregate stability define proteostasis decline in the aging human brain
Anderton E et al. · bioRxiv · 2026-04-18 · DOI 10.64898/2026.03.27.714902
Modell / Design: Human post-mortem hippocampus; Detergent-fractionation proteomics.
Evidenz: low, unreviewed human observation. Begutachtet: NEIN – Preprint.
Unabhängige Reproduktion: not established. Zugriff: Version-2 indexed abstract; version-1 primary full text; version-2 metadata.
AG-S14
Temperature-Dependent Modulation of Cardiac Metabolism, Post-Injury Survival and Regenerative Rate in Axolotls
Dittrich A et al. · Metabolites · 2026-06-13 · DOI 10.3390/metabo16060414
Modell / Design: Adult axolotl cardiac cryoinjury; Temperature intervention; imaging, physiology and histology.
Evidenz: limited-to-moderate, small preclinical groups. Begutachtet: ja.
Unabhängige Reproduktion: Not assessed; author overlap with AG-S06. Zugriff: PMC primary full text and PubMed publication metadata.
Aktueller Bericht mit Quellen und Evidenz · Statusregeln
Neue menschliche Vergleichsmaßstäbe
Vollständige Evidenzeinordnung und Quellen AG-J01 bis AG-J03
- AG-J01 · Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial · 2014-05-27 · Original study
- AG-J02 · A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial · 2015-03-12 · Original study
- AG-J03 · Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial · 2025-07-28 · Original study
22 DOI-eindeutige Arbeiten tragen 25 Quellen-IDs. Aliaspaare: AG-R02 = AG-S10; AG-R06 = AG-S08; AG-R07 = AG-S09. Diese Mehrfachverweise zählen nicht als zusätzliche Studien oder Replikationen.
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