Aging

a.AGINGRESEARCH IN PROGRESS

🇩🇪🇬🇧

An evolving AI research projectBackground · goals · methodsUpdated 7 Oct 2026

Aging — an evolving AI research project

Which biological mechanisms can demonstrably slow or partly reverse age-related functional decline in humans?

Cumulative update · 7 Oct 2026 A human TIMP2 score association is not treatment evidence: 118 of 119 variants are trans markers and APOE is included. The cognitive association comes only from ALFA+; measured plasma values show no significant association. AG-C03/AG-T01 remain 🔵 Level 2. Daily report 7 Oct 2026 →

The leading question · AG-T01 · 🔵 Level 2

Clear harmful proteins. Preserve working synapses?

We connect published studies of TIMP2, microglia and protein turnover. We seek a mechanism that clears harmful cargo while preserving neuronal function. This connection remains an unconfirmed working hypothesis.

Read the evidence and counterarguments →

The axolotl as a model for regeneration. Not evidence of human rejuvenation.

Three findings that move the question forward

Mouse; genetic interventions and TIMP2 administration

TIMP2 changes how microglia handle cargo

TIMP2 affected microglial states and cargo processing in mice. The study also includes a myelin clearance assay following genetic deletion.

Selective removal of harmful synaptic cargo as a cause of functional recovery remains unresolved.
Hemmer, Philippi et al. · 12 Aug 2026

Mouse; neuron-specific protein labeling

Protein stock does not establish degradation flux

Neuronal labeling tracks slowly degraded proteins into microglia. For our model, the key issue is that increased stored cargo can have different causes.

Uptake, degradation and export require separate measurement; this is our methodological inference.
Guldner et al. · 21 Jan 2026

C57BL/6 and SAMP8 mice

Better markers do not establish memory recovery

Urolithin A improved molecular measurements in aged C57BL/6 mice without demonstrating recovery in the memory tests examined.

Early/late comparisons also differ by mouse strain. They establish neither a universal timing window nor proven absence of an effect.
Jara et al. · 5 Mar 2026

The living evidence list

What counteracts age-related functional decline?

Twelve entries distinguish human functional outcomes, preclinical candidates and hypotheses. LIFE, FINGER and US POINTER provide human benchmarks, without establishing a solution to biological aging.

Explore the list →

From findings to better models

A traceable chain of evidence

Each new study should strengthen, constrain or change a specific claim. Independent evidence routes, counterevidence and missing links remain visible. This project conducts no experiments.

Follow the argument →

For professors & leading experts

The research colloquium grows with the project.

16 foundation assignments and 4 new deep dives: challenge causal models, critically read published data and connect conflicting studies. Substantive new findings become dated addition packages with their own Wish-List entries.

Foundation package · 16 assignments →28 Sep 2026 update: 4 research assignments →New courses on the Wish List →

Explore the research journal

Axolotl & regeneration

Tissues · organs · nervous system

Brain & proteins

Proteostasis · synapses · function

Mechanisms of aging

Causes and interactions

Current research

Findings that change the next question

01

Daily research reports

Findings, sources and new inferences

→

Research insights

Critically explore connections

Drugs & interventions

Effects, limitations and evidence

Biotechnology

Tools for causal understanding

?

Open research questions

The decisive knowledge gaps

H

Hypotheses

Proposals with falsification criteria

27

Study register

Primary studies and evidence

±

Risks and conflicting results

Explicitly assess counterevidence

Foundations for school

An accessible entry into biology

University and research

Models, methods and translation

Project status · Read significance and evidence separately

⚪ 1 · Scientifically grounded🔵 2 · Insight / strong hypothesis🟢 3 · Breakthrough in a subproblem🟣 4 · Major research breakthrough🟡 5 · Potential fundamental discovery

Currently levels 1 and 2. Levels 3–5 have not been reached; no rating replaces independent scientific confirmation. All criteria →

Researchers explain the foundations

Institutional talks for context. These older videos are background material; current claims rely on the linked primary studies.

Axolotl regeneration

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YouTube

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Fortfahren Ausblenden

Science Communication Lab · 2018-02 (recorded) · Elly Tanaka examines the experimental questions behind axolotl regeneration. Recorded in 2018; English, 27:57. Use it as methodological background and compare it with the world's current studies.
YouTube

Brain aging in its systemic context

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Fortfahren Ausblenden

Stanford · 2016-11-10 · Tony Wyss-Coray discusses systemic influences on the aging brain. Stanford lecture, published November 10, 2016; English. Historical research background; results in old mice do not establish efficacy in humans.
YouTube

28 selected primary studies, including one labeled preprint. Targeted, non-exhaustive research. Findings, inferences and open hypotheses remain distinct. Study register →

a.AGINGRESEARCH IN PROGRESS

Project overviewGoals & methodsEvidence chain

AI-assisted literature research and model building. No laboratory or clinical studies conducted by this project. No personal treatment plans.

Image credits · Illustrations, not project data: Axolotl — LoKiLeCh (CC BY-SA 3.0) · Neuron — explorebiology (Explore Biology) (CC BY 4.0) · DNA — Biochemlife (CC BY-SA 4.0) · Bovine endothelial cells — Erin Rod (CC BY 4.0)