Aging/Brain & proteins: Unterschied zwischen den Versionen
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[[Aging|← Overview]] | <div class="aging-topbar"><span>[[Aging|← Overview]]</span><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Gehirn & Proteine|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Brain & proteins|🇬🇧]]</span></div></div> | ||
<div class="aging-note">'''Updated research direction · 2026-09-28''' | |||
The earlier synthesis has been critically refined. AG-H01 is a research framework; AG-H02 remains an unconfirmed secondary route. The new target model AG-T01 tests selective protein clearance while preserving functional synapses. [[Aging/Research reports/2026-09-28/Deep dive|Deep dive with counterevidence and decision criteria →]]</div> | |||
== Brain & proteins == | == Brain & proteins == | ||
Version vom 28. September 2026, 22:56 Uhr
Updated research direction · 2026-09-28
The earlier synthesis has been critically refined. AG-H01 is a research framework; AG-H02 remains an unconfirmed secondary route. The new target model AG-T01 tests selective protein clearance while preserving functional synapses. Deep dive with counterevidence and decision criteria →
Brain & proteins
Protein activity, turnover, microglia and neuronal function.
Research programme
- FTL1: Do iron handling, energy metabolism or other functions mediate the effect?
- Deubiquitylases: Does abundance, activity or both change?
- Microglia: Is internalised synaptic material a consequence, protective response or driver of functional loss?
- Human material: Which neuronal subtypes and brain regions carry the signal?
Require temporal resolution, cell-type-specific perturbations, suitable controls and functional endpoints.
Starting sources: AG-S08 · AG-S09 · AG-S10 · AG-S11 · AG-S13
Current report with sources and evidence · Status rules
Altern / Aging research world · Updated 2026-09-28. No self-medication or personal treatment plans.