Altern/Studienübersicht

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Ergänzung vom 28.09.2026

AG-R01

Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice

Hemmer BM; Philippi SM et al. · Nature Communications · 2026-08-12 · DOI 10.1038/s41467-026-74906-z

Modell / Design: Mouse; genetic loss of function and supplementation; original research.

Evidenz: mechanistic intervention; moderate, preclinical.

Zugriff / Grenzen: publisher full text · Opposing substrate directions in Results; see bilingual dossier. Not silently corrected.

Originalstudie

AG-R02

Ageing promotes microglial accumulation of slow-degrading synaptic proteins

Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9

Modell / Design: Mouse; neuron-specific protein tracing; original research.

Evidenz: mechanistic tracing; moderate, preclinical.

Zugriff / Grenzen: publisher full text

Originalstudie

AG-R03

Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment

Jara C et al. · npj Aging · 2026-03-05 · DOI 10.1038/s41514-026-00351-3

Modell / Design: C57BL/6 and SAMP8 mice; original research.

Evidenz: intervention; moderate within model, timing comparison confounded.

Zugriff / Grenzen: publisher full text

Originalstudie

AG-R04

The mitochondrial unfolded protein response in human microglia disrupts neuronal–glial communication and promotes senescence

Perez J MJ et al. · Nature Neuroscience · 2026-06-26 · DOI 10.1038/s41593-026-02320-1

Modell / Design: Human cellular models; induced mitochondrial stress; original research.

Evidenz: mechanistic intervention; moderate in vitro, low aging translation.

Zugriff / Grenzen: publisher full text

Originalstudie

AG-R05

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

Castellano JM et al. · Nature · 2017-04-19 · DOI 10.1038/nature22067

Modell / Design: Aged mouse; original research.

Evidenz: preclinical intervention; access-limited appraisal here.

Zugriff / Grenzen: publisher abstract and bibliographic metadata

Originalstudie

AG-R06

Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains

Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y

Modell / Design: Vertebrate brain and cellular models; original research.

Evidenz: mechanistic intervention; moderate, preclinical.

Zugriff / Grenzen: publisher full text

Originalstudie

AG-R07

Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment

Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z

Modell / Design: Mouse and cellular models; original research.

Evidenz: mechanistic intervention; moderate, preclinical.

Zugriff / Grenzen: publisher full text

Originalstudie

AG-R08

Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging

Britton R et al. · eNeuro · 2023-06-15 · DOI 10.1523/ENEURO.0031-23.2023

Modell / Design: Aged male C57BL/6J mice; original research.

Evidenz: preclinical intervention; partial-access appraisal.

Zugriff / Grenzen: PubMed abstract/figure captions and indexed publisher excerpts; publisher open returned 403; PMC returned CAPTCHA

Originalstudie

Studienübersicht

DOI, Datum, Modell, Design, Evidenz und Peer-Review.

Publikationsdatum bezeichnet das erste Online-Datum, beim Preprint die ausgewiesene Fassung. Stärke bezieht sich auf den jeweiligen Aussagebereich; sämtliche Literaturbefunde sind ⚪ Projektstufe 1. „Nicht beurteilt“ ist keine Bestätigung und keine Widerlegung.

AG-S01

Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration

Yu Q et al. · Developmental Cell · 2023-10-24 · DOI 10.1016/j.devcel.2023.09.009

Modell / Design: Axolotl limb; Gain/loss of function.

Evidenz: moderate, preclinical mechanism. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Primary abstract and article metadata.

Originalquelle

AG-S02

Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration

Wei X et al. · Science · 2022-09-02 · DOI 10.1126/science.abp9444

Modell / Design: Axolotl telencephalon; Spatial single-cell transcriptomics.

Evidenz: moderate, descriptive animal atlas. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Primary abstract and article metadata.

Originalquelle

AG-S03

Molecular basis of positional memory in limb regeneration

Otsuki L et al. · Nature · 2025-05-21 · DOI 10.1038/s41586-025-09036-5

Modell / Design: Axolotl limb; Lineage analysis and signalling perturbation.

Evidenz: moderate, preclinical mechanism. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text and primary abstract.

Originalquelle

AG-S04

Adrenergic signaling coordinates distant and local responses to amputation in axolotl

Payzin-Dogru D et al. · Cell · 2025-10-24 · DOI 10.1016/j.cell.2025.09.025

Modell / Design: Axolotl amputation; Systemic and local signalling perturbation.

Evidenz: moderate, preclinical mechanism. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher summary; PMC publication metadata.

Originalquelle

AG-S05

Neuronal activation in the axolotl brain promotes tail regeneration

Walker SE et al. · npj Regenerative Medicine · 2025-05-08 · DOI 10.1038/s41536-025-00413-2

Modell / Design: Axolotl brain and tail; Neural mapping and pharmacological perturbation.

Evidenz: moderate, preclinical mechanism. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.

Originalquelle

AG-S06

Metabolic changes during cardiac regeneration in the axolotl

Dittrich A et al. · Developmental Dynamics · 2025-03-22 · DOI 10.1002/dvdy.70020

Modell / Design: Axolotl cardiac cryoinjury; Metabolic profiling and oxygen intervention.

Evidenz: limited-to-moderate, exploratory animal study. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher metadata and PMC indexed full text.

Originalquelle

AG-S07

A characterization of axolotl digit regeneration: conserved mechanisms, divergent patterning, and a critical role for hedgehog signaling

Griffiths JR et al. · npj Regenerative Medicine · 2026-03-25 · DOI 10.1038/s41536-026-00461-2

Modell / Design: Juvenile axolotl digits; Anatomical comparison and hedgehog perturbation.

Evidenz: moderate, endpoint- and anatomy-specific animal evidence. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.

Originalquelle

AG-S08

Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains

Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y

Modell / Design: Mouse, killifish, human iPSC-derived neurons; Activity-based proteomics and perturbation.

Evidenz: moderate, multi-model preclinical mechanism. Begutachtet: ja.

Unabhängige Reproduktion: Multiple cohorts/models within one paper; external replication not assessed. Zugriff: Publisher full text.

Originalquelle

AG-S09

Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment

Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z

Modell / Design: Mouse hippocampus and primary neurons; Viral/genetic manipulation and behavioural readouts.

Evidenz: moderate, preclinical intervention. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.

Originalquelle

AG-S10

Ageing promotes microglial accumulation of slow-degrading synaptic proteins

Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9

Modell / Design: Mouse neuronal proteome; complementary human material; Cell-specific pulse-chase proteomics and microglial analysis.

Evidenz: moderate, descriptive/longitudinal protein-tracing animal evidence. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.

Originalquelle

AG-S11

Single-cell transcriptomic and genomic changes in the ageing human brain

Jeffries AM et al. · Nature · 2025-09-03 · DOI 10.1038/s41586-025-09435-8

Modell / Design: Human post-mortem prefrontal cortex; snRNA-seq, single-cell genome sequencing, spatial validation.

Evidenz: moderate, cross-sectional human observation. Begutachtet: ja.

Unabhängige Reproduktion: Within-paper orthogonal validation; external replication not assessed. Zugriff: Publisher full text.

Originalquelle

AG-S12

Organ-specific proteomic aging clocks predict disease and longevity across diverse populations

Wang Y et al. · Nature Aging · 2025-11-26 · DOI 10.1038/s43587-025-01016-8

Modell / Design: UK, Chinese and US human cohorts; Observational plasma proteomics with external cohort validation.

Evidenz: moderate-to-strong for prediction; not causal or interventional. Begutachtet: ja.

Unabhängige Reproduktion: External cohorts within one publication; distinct external team not established. Zugriff: Publisher full text.

Originalquelle

AG-S13

Shifts in protein aggregate stability define proteostasis decline in the aging human brain

Anderton E et al. · bioRxiv · 2026-04-18 · DOI 10.64898/2026.03.27.714902

Modell / Design: Human post-mortem hippocampus; Detergent-fractionation proteomics.

Evidenz: low, unreviewed human observation. Begutachtet: NEIN – Preprint.

Unabhängige Reproduktion: not established. Zugriff: Version-2 indexed abstract; version-1 primary full text; version-2 metadata.

Originalquelle

AG-S14

Temperature-Dependent Modulation of Cardiac Metabolism, Post-Injury Survival and Regenerative Rate in Axolotls

Dittrich A et al. · Metabolites · 2026-06-13 · DOI 10.3390/metabo16060414

Modell / Design: Adult axolotl cardiac cryoinjury; Temperature intervention; imaging, physiology and histology.

Evidenz: limited-to-moderate, small preclinical groups. Begutachtet: ja.

Unabhängige Reproduktion: Not assessed; author overlap with AG-S06. Zugriff: PMC primary full text and PubMed publication metadata.

Originalquelle

Aktueller Bericht mit Quellen und Evidenz · Statusregeln

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Forschungswelt Altern / Aging · Stand 28.09.2026. Keine Selbstmedikation oder persönlichen Therapiepläne.