Aging/Daily research reports: Unterschied zwischen den Versionen
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<div class=" | <div class="aj-masthead"><div class="aj-brand"><span class="aj-monogram">[[Aging|a.]]</span><span>[[Aging|AGING]]<small>RESEARCH IN PROGRESS</small></span></div><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Tägliche Forschungsberichte|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Daily research reports|🇬🇧]]</span></div></div> | ||
<div class="aj-context"><strong>An evolving AI research project</strong>[[Aging/About the project|Background · goals · methods]]<span>Updated 23 Oct 2026</span></div> | |||
<h1>Research reports & archive</h1> | |||
<div class="aj-deck">Connect the literature. Challenge assumptions. Understand function.</div> | |||
<div class="aj-article"> | |||
<div class="aging-note">From 23 October 2026, research advances once a week, on Fridays at 08:00 Europe/Berlin. Earlier daily reports remain in the archive.</div> | |||
<div class="aging-note">'''Cumulative update · 22 Oct 2026''' | |||
The methods audit separates donor comparisons from spatial spot analyses. Technical correction does not automatically establish independent evidence. Context hypothesis AG-T01 remains 🔵 Level 2; literature AG-D10 ⚪ Level 1, without intervention evidence. [[Aging/Research reports/2026-10-22|Daily report 22 Oct 2026 →]]</div> | |||
<div class="aging-note">'''Updated research direction · 2026-09-28''' | <div class="aging-note">'''Updated research direction · 2026-09-28''' | ||
| Zeile 7: | Zeile 19: | ||
The earlier synthesis has been critically refined. AG-H01 is a research framework; AG-H02 remains an unconfirmed secondary route. The new target model AG-T01 tests selective protein clearance while preserving functional synapses. [[Aging/Research reports/2026-09-28/Deep dive|Deep dive with counterevidence and decision criteria →]]</div> | The earlier synthesis has been critically refined. AG-H01 is a research framework; AG-H02 remains an unconfirmed secondary route. The new target model AG-T01 tests selective protein clearance while preserving functional synapses. [[Aging/Research reports/2026-09-28/Deep dive|Deep dive with counterevidence and decision criteria →]]</div> | ||
Dated, traceable reports in German and English. | Dated, traceable reports in German and English. | ||
* [[Aging/Research reports/2026-10-22|22 Oct 2026 – Microglia: Spots are not people]] | |||
* [[Aging/Research reports/2026-10-21|21 Oct 2026 – Microglia: When does a cell state protect?]] | |||
* [[Aging/Research reports/2026-10-20|20 Oct 2026 – Retaining age does not establish functional rescue]] | |||
* [[Aging/Research reports/2026-10-19|19 Oct 2026 – Wound closure is not yet evidence of restored function]] | |||
* [[Aging/Research reports/2026-10-18|18 Oct 2026 – Comparing wound closure: what counts as one outcome?]] | |||
* [[Aging/Research reports/2026-10-17|17 Oct 2026 – Removing senescent cells: which cells, which benefit?]] | |||
* [[Aging/Research reports/2026-10-16|16 Oct 2026 – When does senescence help healing?]] | |||
* [[Aging/Research reports/2026-10-15|15 Oct 2026 – What counts as independent confirmation?]] | |||
* [[Aging/Research reports/2026-10-14|14 Oct 2026 – A cell map is not yet evidence of circuit repair]] | |||
* [[Aging/Research reports/2026-10-13|13 Oct 2026 – New neurons are only the beginning]] | |||
* [[Aging/Research reports/2026-10-12|12 Oct 2026 – TIMP2: Resolve sample structure before testing effects]] | |||
* [[Aging/Research reports/2026-10-11|11 Oct 2026 – TIMP2: What two datasets cannot establish together]] | |||
* [[Aging/Research reports/2026-10-10|10 Oct 2026 – TIMP2: Three studies—how independent is the evidence?]] | |||
* [[Aging/Research reports/2026-10-09|9 Oct 2026 – TIMP2: A memory benefit—but through what mechanism, and for how long?]] | |||
* [[Aging/Research reports/2026-10-08|8 Oct 2026 – What would a TIMP2 countercheck need to show?]] | |||
* [[Aging/Research reports/2026-10-07|7 Oct 2026 – Does the genetic score implicate TIMP2—or other pathways?]] | |||
* [[Aging/Research reports/2026-10-06|6 Oct 2026 – What is the claimed memory benefit compared with?]] | |||
* [[Aging/Research reports/2026-10-05|5 Oct 2026 – What remains after a second regeneration?]] | |||
* [[Aging/Research reports/2026-10-04|4 Oct 2026 – Does the cell change — or does the tissue regenerate?]] | |||
* [[Aging/Research reports/2026-10-03|2026-10-03 – How can repair stay in the right place?]] | |||
* [[Aging/Research reports/2026-10-02|2026-10-02 – Targeting tau degradation — with what functional evidence?]] | |||
* [[Aging/Research reports/2026-10-01|1 Oct 2026 – Protein degradation with functional evidence?]] | |||
* [[Aging/Research reports/2026-09-30|30 Sep 2026 – Where does the tau go?]] | |||
* [[Aging/Research reports/2026-09-29|29 Sep 2026 – Disposal or redistribution?]] | |||
* [[Aging/Research reports/2026-09-28|2026-09-28 – Axolotl regeneration, brain aging and proteins]] | * [[Aging/Research reports/2026-09-28|2026-09-28 – Axolotl regeneration, brain aging and proteins]] | ||
Reports are archived by date. Corrections receive a visible note; absence of new findings is reported honestly. Each report includes sources, publication dates, evidence, project levels, counterevidence and next checks. | Reports are archived by date. Corrections receive a visible note; absence of new findings is reported honestly. Each report includes sources, publication dates, evidence, project levels, counterevidence and next checks. | ||
[[Aging/Research reports/2026- | [[Aging/Research reports/2026-10-22|Current report with sources and evidence]] · [[Aging/Research status|Status rules]] | ||
== Cumulative update · 28 Sep 2026 == | |||
[[Aging/Evidence chain|New evidence chain and next literature checks]] · [[Aging/Approaches to aging|LIFE, FINGER, US POINTER: interpreting human functional outcomes]] | |||
⚪ Level 1: published human findings. 🔵 Level 2: AG-T01 remains unconfirmed. This update documents literature analysis, not a newly conducted study. | |||
---- | </div> | ||
<div class="aj-section-title"><h2>Continue exploring</h2></div><div class="aj-tiles"><div class="aj-tile"><div class="aj-thumb">[[File:Bovine Pulmonary Artery Endothelial Cells Fluorescent Image.jpg|120px|frameless|link=Aging/Approaches to aging|alt=Fluorescence micrograph of bovine endothelial cells with labeled nuclei, actin and mitochondria.]]</div><div><div class="aj-tile-title">[[Aging/Approaches to aging|Approaches to aging]]</div><div class="aj-tile-desc">Evidence and functional outcomes</div></div></div><div class="aj-tile"><div class="aj-thumb aj-type-thumb">[[Aging/Evidence chain|→]]</div><div><div class="aj-tile-title">[[Aging/Evidence chain|Evidence chain]]</div><div class="aj-tile-desc">How studies generate new questions</div></div></div><div class="aj-tile"><div class="aj-thumb">[[File:DNA double helix.svg|120px|frameless|link=Aging/Research colloquium|alt=Schematic illustration of a DNA double helix.]]</div><div><div class="aj-tile-title">[[Aging/Research colloquium|Research colloquium]]</div><div class="aj-tile-desc">16 foundation assignments + 4 new deep dives</div></div></div></div> | |||
<div class="aj-footer"><div class="aj-brand"><span class="aj-monogram">[[Aging|a.]]</span><span>[[Aging|AGING]]<small>RESEARCH IN PROGRESS</small></span></div><div class="aj-context">[[Aging|Project overview]][[Aging/About the project|Goals & methods]][[Aging/Evidence chain|Evidence chain]]</div><div class="aj-meta">AI-assisted literature research and model building. No laboratory or clinical studies conducted by this project. No personal treatment plans.</div><div class="aj-credits">Image credits · Illustrations, not project data: [https://commons.wikimedia.org/wiki/File:Axolotl_Portrait.jpg Axolotl] — LoKiLeCh ([https://creativecommons.org/licenses/by-sa/3.0/ CC BY-SA 3.0]) · [https://commons.wikimedia.org/wiki/File:XBio_illustration_%E2%80%93_Neuron.png Neuron] — explorebiology (Explore Biology) ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0]) · [https://commons.wikimedia.org/wiki/File:DNA_double_helix.svg DNA] — Biochemlife ([https://creativecommons.org/licenses/by-sa/4.0/ CC BY-SA 4.0]) · [https://commons.wikimedia.org/wiki/File:Bovine_Pulmonary_Artery_Endothelial_Cells_Fluorescent_Image.jpg Bovine endothelial cells] — Erin Rod ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0])</div></div> | |||
</div> | </div> | ||
[[Category:Altern / Aging]] | [[Category:Altern / Aging]] | ||
Aktuelle Version vom 23. Oktober 2026, 14:31 Uhr
An evolving AI research projectBackground · goals · methodsUpdated 23 Oct 2026
Research reports & archive
Connect the literature. Challenge assumptions. Understand function.
From 23 October 2026, research advances once a week, on Fridays at 08:00 Europe/Berlin. Earlier daily reports remain in the archive.
Cumulative update · 22 Oct 2026
The methods audit separates donor comparisons from spatial spot analyses. Technical correction does not automatically establish independent evidence. Context hypothesis AG-T01 remains 🔵 Level 2; literature AG-D10 ⚪ Level 1, without intervention evidence. Daily report 22 Oct 2026 →
Updated research direction · 2026-09-28
The earlier synthesis has been critically refined. AG-H01 is a research framework; AG-H02 remains an unconfirmed secondary route. The new target model AG-T01 tests selective protein clearance while preserving functional synapses. Deep dive with counterevidence and decision criteria →
Dated, traceable reports in German and English.
- 22 Oct 2026 – Microglia: Spots are not people
- 21 Oct 2026 – Microglia: When does a cell state protect?
- 20 Oct 2026 – Retaining age does not establish functional rescue
- 19 Oct 2026 – Wound closure is not yet evidence of restored function
- 18 Oct 2026 – Comparing wound closure: what counts as one outcome?
- 17 Oct 2026 – Removing senescent cells: which cells, which benefit?
- 16 Oct 2026 – When does senescence help healing?
- 15 Oct 2026 – What counts as independent confirmation?
- 14 Oct 2026 – A cell map is not yet evidence of circuit repair
- 13 Oct 2026 – New neurons are only the beginning
- 12 Oct 2026 – TIMP2: Resolve sample structure before testing effects
- 11 Oct 2026 – TIMP2: What two datasets cannot establish together
- 10 Oct 2026 – TIMP2: Three studies—how independent is the evidence?
- 9 Oct 2026 – TIMP2: A memory benefit—but through what mechanism, and for how long?
- 8 Oct 2026 – What would a TIMP2 countercheck need to show?
- 7 Oct 2026 – Does the genetic score implicate TIMP2—or other pathways?
- 6 Oct 2026 – What is the claimed memory benefit compared with?
- 5 Oct 2026 – What remains after a second regeneration?
- 4 Oct 2026 – Does the cell change — or does the tissue regenerate?
- 2026-10-03 – How can repair stay in the right place?
- 2026-10-02 – Targeting tau degradation — with what functional evidence?
- 1 Oct 2026 – Protein degradation with functional evidence?
- 30 Sep 2026 – Where does the tau go?
- 29 Sep 2026 – Disposal or redistribution?
- 2026-09-28 – Axolotl regeneration, brain aging and proteins
Reports are archived by date. Corrections receive a visible note; absence of new findings is reported honestly. Each report includes sources, publication dates, evidence, project levels, counterevidence and next checks.
Current report with sources and evidence · Status rules
Cumulative update · 28 Sep 2026
New evidence chain and next literature checks · LIFE, FINGER, US POINTER: interpreting human functional outcomes
⚪ Level 1: published human findings. 🔵 Level 2: AG-T01 remains unconfirmed. This update documents literature analysis, not a newly conducted study.
Continue exploring
Evidence and functional outcomes
How studies generate new questions
16 foundation assignments + 4 new deep dives
