Altern/Studienübersicht: Unterschied zwischen den Versionen
Glanz (Diskussion | Beiträge) Aging – freigegebene Erstveröffentlichung 6faa740d2c794e56888ab060b71d3212 347a4110f8e6 |
Glanz (Diskussion | Beiträge) Aging daily 6de7ad6c60c644adbcd2368820f28bd1 347a4110f8e6 |
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<div class="aging-research-world" lang="de" | <div class="aging-research-world aging-journal" lang="de"> | ||
[[Altern| | <div class="aj-masthead"><div class="aj-brand"><span class="aj-monogram">[[Altern|a.]]</span><span>[[Altern|AGING]]<small>FORSCHUNG IM WANDEL</small></span></div><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Studienübersicht|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Study register|🇬🇧]]</span></div></div> | ||
<div class="aj-context"><strong>Fortlaufendes KI-Forschungsprojekt</strong>[[Altern/Über das Projekt|Hintergründe · Ziele · Arbeitsweise]]<span>Stand 28.09.2026</span></div> | |||
<h1>Ergänzung vom 28.09.2026</h1> | |||
<div class="aj-deck">Literatur verbinden. Annahmen herausfordern. Funktion verstehen.</div> | |||
<div class="aj-article"> | |||
=== AG-R01 === | |||
'''Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice''' | |||
Hemmer BM; Philippi SM et al. · Nature Communications · 2026-08-12 · DOI 10.1038/s41467-026-74906-z | |||
Modell / Design: Mouse; genetic loss of function and supplementation; original research. | |||
Evidenz: mechanistic intervention; moderate, preclinical. | |||
Zugriff / Grenzen: publisher full text · Opposing substrate directions in Results; see bilingual dossier. Not silently corrected. | |||
[https://www.nature.com/articles/s41467-026-74906-z Originalstudie] | |||
=== AG-R02 === | |||
'''Ageing promotes microglial accumulation of slow-degrading synaptic proteins''' | |||
Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9 | |||
Modell / Design: Mouse; neuron-specific protein tracing; original research. | |||
Evidenz: mechanistic tracing; moderate, preclinical. | |||
Zugriff / Grenzen: publisher full text | |||
[https://www.nature.com/articles/s41586-025-09987-9 Originalstudie] | |||
=== AG-R03 === | |||
'''Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment''' | |||
Jara C et al. · npj Aging · 2026-03-05 · DOI 10.1038/s41514-026-00351-3 | |||
Modell / Design: C57BL/6 and SAMP8 mice; original research. | |||
Evidenz: intervention; moderate within model, timing comparison confounded. | |||
Zugriff / Grenzen: publisher full text | |||
[https://www.nature.com/articles/s41514-026-00351-3 Originalstudie] | |||
=== AG-R04 === | |||
'''The mitochondrial unfolded protein response in human microglia disrupts neuronal–glial communication and promotes senescence''' | |||
Perez J MJ et al. · Nature Neuroscience · 2026-06-26 · DOI 10.1038/s41593-026-02320-1 | |||
Modell / Design: Human cellular models; induced mitochondrial stress; original research. | |||
Evidenz: mechanistic intervention; moderate in vitro, low aging translation. | |||
Zugriff / Grenzen: publisher full text | |||
[https://www.nature.com/articles/s41593-026-02320-1 Originalstudie] | |||
=== AG-R05 === | |||
'''Human umbilical cord plasma proteins revitalize hippocampal function in aged mice''' | |||
Castellano JM et al. · Nature · 2017-04-19 · DOI 10.1038/nature22067 | |||
Modell / Design: Aged mouse; original research. | |||
Evidenz: preclinical intervention; access-limited appraisal here. | |||
Zugriff / Grenzen: publisher abstract and bibliographic metadata | |||
[https://www.nature.com/articles/nature22067 Originalstudie] | |||
=== AG-R06 === | |||
'''Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains''' | |||
Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y | |||
Modell / Design: Vertebrate brain and cellular models; original research. | |||
Evidenz: mechanistic intervention; moderate, preclinical. | |||
Zugriff / Grenzen: publisher full text | |||
[https://www.nature.com/articles/s41467-026-71921-y Originalstudie] | |||
=== AG-R07 === | |||
'''Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment''' | |||
Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z | |||
Modell / Design: Mouse and cellular models; original research. | |||
Evidenz: mechanistic intervention; moderate, preclinical. | |||
Zugriff / Grenzen: publisher full text | |||
[https://www.nature.com/articles/s43587-025-00940-z Originalstudie] | |||
=== AG-R08 === | |||
'''Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging''' | |||
Britton R et al. · eNeuro · 2023-06-15 · DOI 10.1523/ENEURO.0031-23.2023 | |||
Modell / Design: Aged male C57BL/6J mice; original research. | |||
Evidenz: preclinical intervention; partial-access appraisal. | |||
Zugriff / Grenzen: PubMed abstract/figure captions and indexed publisher excerpts; publisher open returned 403; PMC returned CAPTCHA | |||
[https://www.eneuro.org/content/10/6/ENEURO.0031-23.2023 Originalstudie] | |||
<div class="aj-return"><div class="aj-brand"><span class="aj-monogram">[[Altern|a.]]</span><span>[[Altern|AGING]]<small>FORSCHUNG IM WANDEL</small></span></div><span>[[Altern|Zur Projektübersicht →]]</span></div> | |||
== Studienübersicht == | == Studienübersicht == | ||
| Zeile 195: | Zeile 305: | ||
[[Altern/Forschungsberichte/2026-09-28|Aktueller Bericht mit Quellen und Evidenz]] · [[Altern/Forschungsstatus|Statusregeln]] | [[Altern/Forschungsberichte/2026-09-28|Aktueller Bericht mit Quellen und Evidenz]] · [[Altern/Forschungsstatus|Statusregeln]] | ||
---- | == Neue menschliche Vergleichsmaßstäbe == | ||
[[Altern/Ansätze gegen Altern|Vollständige Evidenzeinordnung und Quellen AG-J01 bis AG-J03]] | |||
* AG-J01 · Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial · 2014-05-27 · [https://jamanetwork.com/journals/jama/fullarticle/1875328 Original study] | |||
* AG-J02 · A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial · 2015-03-12 · [https://www.sciencedirect.com/science/article/pii/S0140673615604615 Original study] | |||
* AG-J03 · Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial · 2025-07-28 · [https://jamanetwork.com/journals/jama/fullarticle/2837046 Original study] | |||
22 DOI-eindeutige Arbeiten tragen 25 Quellen-IDs. Aliaspaare: AG-R02 = AG-S10; AG-R06 = AG-S08; AG-R07 = AG-S09. Diese Mehrfachverweise zählen nicht als zusätzliche Studien oder Replikationen. | |||
</div> | |||
<div class="aj-section-title"><h2>Weiterdenken</h2></div><div class="aj-tiles"><div class="aj-tile"><div class="aj-thumb">[[File:Bovine Pulmonary Artery Endothelial Cells Fluorescent Image.jpg|120px|frameless|link=Altern/Ansätze gegen Altern|alt=Fluoreszenzaufnahme boviner Endothelzellen mit markierten Zellkernen, Aktin und Mitochondrien.]]</div><div><div class="aj-tile-title">[[Altern/Ansätze gegen Altern|Ansätze gegen Altern]]</div><div class="aj-tile-desc">Evidenz und Funktionsendpunkte</div></div></div><div class="aj-tile"><div class="aj-thumb aj-type-thumb">[[Altern/Erkenntniskette|→]]</div><div><div class="aj-tile-title">[[Altern/Erkenntniskette|Erkenntniskette]]</div><div class="aj-tile-desc">Wie Studien neue Fragen erzeugen</div></div></div><div class="aj-tile"><div class="aj-thumb">[[File:DNA double helix.svg|120px|frameless|link=Altern/Forschungskolleg|alt=Schematische Darstellung einer DNA-Doppelhelix.]]</div><div><div class="aj-tile-title">[[Altern/Forschungskolleg|Forschungskolleg]]</div><div class="aj-tile-desc">16 Basisaufträge + 4 neue Vertiefungen</div></div></div></div> | |||
<div class="aj-footer"><div class="aj-brand"><span class="aj-monogram">[[Altern|a.]]</span><span>[[Altern|AGING]]<small>FORSCHUNG IM WANDEL</small></span></div><div class="aj-context">[[Altern|Projektübersicht]][[Altern/Über das Projekt|Ziele & Methoden]][[Altern/Erkenntniskette|Erkenntniskette]]</div><div class="aj-meta">KI-gestützte Literaturarbeit und Modellbildung. Keine eigenen Labor- oder klinischen Studien. Keine persönlichen Therapiepläne.</div><div class="aj-credits">Bildnachweise · Illustrationen, keine Projektdaten: [https://commons.wikimedia.org/wiki/File:Axolotl_Portrait.jpg Axolotl] — LoKiLeCh ([https://creativecommons.org/licenses/by-sa/3.0/ CC BY-SA 3.0]) · [https://commons.wikimedia.org/wiki/File:XBio_illustration_%E2%80%93_Neuron.png Nervenzelle] — explorebiology (Explore Biology) ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0]) · [https://commons.wikimedia.org/wiki/File:DNA_double_helix.svg DNA] — Biochemlife ([https://creativecommons.org/licenses/by-sa/4.0/ CC BY-SA 4.0]) · [https://commons.wikimedia.org/wiki/File:Bovine_Pulmonary_Artery_Endothelial_Cells_Fluorescent_Image.jpg Bovine Endothelzellen] — Erin Rod ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0])</div></div> | |||
</div> | </div> | ||
[[Category:Altern / Aging]] | [[Category:Altern / Aging]] | ||
Aktuelle Version vom 28. September 2026, 23:29 Uhr
Ergänzung vom 28.09.2026
AG-R01
Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice
Hemmer BM; Philippi SM et al. · Nature Communications · 2026-08-12 · DOI 10.1038/s41467-026-74906-z
Modell / Design: Mouse; genetic loss of function and supplementation; original research.
Evidenz: mechanistic intervention; moderate, preclinical.
Zugriff / Grenzen: publisher full text · Opposing substrate directions in Results; see bilingual dossier. Not silently corrected.
AG-R02
Ageing promotes microglial accumulation of slow-degrading synaptic proteins
Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9
Modell / Design: Mouse; neuron-specific protein tracing; original research.
Evidenz: mechanistic tracing; moderate, preclinical.
Zugriff / Grenzen: publisher full text
AG-R03
Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment
Jara C et al. · npj Aging · 2026-03-05 · DOI 10.1038/s41514-026-00351-3
Modell / Design: C57BL/6 and SAMP8 mice; original research.
Evidenz: intervention; moderate within model, timing comparison confounded.
Zugriff / Grenzen: publisher full text
AG-R04
The mitochondrial unfolded protein response in human microglia disrupts neuronal–glial communication and promotes senescence
Perez J MJ et al. · Nature Neuroscience · 2026-06-26 · DOI 10.1038/s41593-026-02320-1
Modell / Design: Human cellular models; induced mitochondrial stress; original research.
Evidenz: mechanistic intervention; moderate in vitro, low aging translation.
Zugriff / Grenzen: publisher full text
AG-R05
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
Castellano JM et al. · Nature · 2017-04-19 · DOI 10.1038/nature22067
Modell / Design: Aged mouse; original research.
Evidenz: preclinical intervention; access-limited appraisal here.
Zugriff / Grenzen: publisher abstract and bibliographic metadata
AG-R06
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains
Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y
Modell / Design: Vertebrate brain and cellular models; original research.
Evidenz: mechanistic intervention; moderate, preclinical.
Zugriff / Grenzen: publisher full text
AG-R07
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z
Modell / Design: Mouse and cellular models; original research.
Evidenz: mechanistic intervention; moderate, preclinical.
Zugriff / Grenzen: publisher full text
AG-R08
Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging
Britton R et al. · eNeuro · 2023-06-15 · DOI 10.1523/ENEURO.0031-23.2023
Modell / Design: Aged male C57BL/6J mice; original research.
Evidenz: preclinical intervention; partial-access appraisal.
Zugriff / Grenzen: PubMed abstract/figure captions and indexed publisher excerpts; publisher open returned 403; PMC returned CAPTCHA
Studienübersicht
DOI, Datum, Modell, Design, Evidenz und Peer-Review.
Publikationsdatum bezeichnet das erste Online-Datum, beim Preprint die ausgewiesene Fassung. Stärke bezieht sich auf den jeweiligen Aussagebereich; sämtliche Literaturbefunde sind ⚪ Projektstufe 1. „Nicht beurteilt“ ist keine Bestätigung und keine Widerlegung.
AG-S01
Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration
Yu Q et al. · Developmental Cell · 2023-10-24 · DOI 10.1016/j.devcel.2023.09.009
Modell / Design: Axolotl limb; Gain/loss of function.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Primary abstract and article metadata.
AG-S02
Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration
Wei X et al. · Science · 2022-09-02 · DOI 10.1126/science.abp9444
Modell / Design: Axolotl telencephalon; Spatial single-cell transcriptomics.
Evidenz: moderate, descriptive animal atlas. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Primary abstract and article metadata.
AG-S03
Molecular basis of positional memory in limb regeneration
Otsuki L et al. · Nature · 2025-05-21 · DOI 10.1038/s41586-025-09036-5
Modell / Design: Axolotl limb; Lineage analysis and signalling perturbation.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text and primary abstract.
AG-S04
Adrenergic signaling coordinates distant and local responses to amputation in axolotl
Payzin-Dogru D et al. · Cell · 2025-10-24 · DOI 10.1016/j.cell.2025.09.025
Modell / Design: Axolotl amputation; Systemic and local signalling perturbation.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher summary; PMC publication metadata.
AG-S05
Neuronal activation in the axolotl brain promotes tail regeneration
Walker SE et al. · npj Regenerative Medicine · 2025-05-08 · DOI 10.1038/s41536-025-00413-2
Modell / Design: Axolotl brain and tail; Neural mapping and pharmacological perturbation.
Evidenz: moderate, preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S06
Metabolic changes during cardiac regeneration in the axolotl
Dittrich A et al. · Developmental Dynamics · 2025-03-22 · DOI 10.1002/dvdy.70020
Modell / Design: Axolotl cardiac cryoinjury; Metabolic profiling and oxygen intervention.
Evidenz: limited-to-moderate, exploratory animal study. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher metadata and PMC indexed full text.
AG-S07
A characterization of axolotl digit regeneration: conserved mechanisms, divergent patterning, and a critical role for hedgehog signaling
Griffiths JR et al. · npj Regenerative Medicine · 2026-03-25 · DOI 10.1038/s41536-026-00461-2
Modell / Design: Juvenile axolotl digits; Anatomical comparison and hedgehog perturbation.
Evidenz: moderate, endpoint- and anatomy-specific animal evidence. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S08
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains
Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y
Modell / Design: Mouse, killifish, human iPSC-derived neurons; Activity-based proteomics and perturbation.
Evidenz: moderate, multi-model preclinical mechanism. Begutachtet: ja.
Unabhängige Reproduktion: Multiple cohorts/models within one paper; external replication not assessed. Zugriff: Publisher full text.
AG-S09
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z
Modell / Design: Mouse hippocampus and primary neurons; Viral/genetic manipulation and behavioural readouts.
Evidenz: moderate, preclinical intervention. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S10
Ageing promotes microglial accumulation of slow-degrading synaptic proteins
Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9
Modell / Design: Mouse neuronal proteome; complementary human material; Cell-specific pulse-chase proteomics and microglial analysis.
Evidenz: moderate, descriptive/longitudinal protein-tracing animal evidence. Begutachtet: ja.
Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.
AG-S11
Single-cell transcriptomic and genomic changes in the ageing human brain
Jeffries AM et al. · Nature · 2025-09-03 · DOI 10.1038/s41586-025-09435-8
Modell / Design: Human post-mortem prefrontal cortex; snRNA-seq, single-cell genome sequencing, spatial validation.
Evidenz: moderate, cross-sectional human observation. Begutachtet: ja.
Unabhängige Reproduktion: Within-paper orthogonal validation; external replication not assessed. Zugriff: Publisher full text.
AG-S12
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
Wang Y et al. · Nature Aging · 2025-11-26 · DOI 10.1038/s43587-025-01016-8
Modell / Design: UK, Chinese and US human cohorts; Observational plasma proteomics with external cohort validation.
Evidenz: moderate-to-strong for prediction; not causal or interventional. Begutachtet: ja.
Unabhängige Reproduktion: External cohorts within one publication; distinct external team not established. Zugriff: Publisher full text.
AG-S13
Shifts in protein aggregate stability define proteostasis decline in the aging human brain
Anderton E et al. · bioRxiv · 2026-04-18 · DOI 10.64898/2026.03.27.714902
Modell / Design: Human post-mortem hippocampus; Detergent-fractionation proteomics.
Evidenz: low, unreviewed human observation. Begutachtet: NEIN – Preprint.
Unabhängige Reproduktion: not established. Zugriff: Version-2 indexed abstract; version-1 primary full text; version-2 metadata.
AG-S14
Temperature-Dependent Modulation of Cardiac Metabolism, Post-Injury Survival and Regenerative Rate in Axolotls
Dittrich A et al. · Metabolites · 2026-06-13 · DOI 10.3390/metabo16060414
Modell / Design: Adult axolotl cardiac cryoinjury; Temperature intervention; imaging, physiology and histology.
Evidenz: limited-to-moderate, small preclinical groups. Begutachtet: ja.
Unabhängige Reproduktion: Not assessed; author overlap with AG-S06. Zugriff: PMC primary full text and PubMed publication metadata.
Aktueller Bericht mit Quellen und Evidenz · Statusregeln
Neue menschliche Vergleichsmaßstäbe
Vollständige Evidenzeinordnung und Quellen AG-J01 bis AG-J03
- AG-J01 · Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial · 2014-05-27 · Original study
- AG-J02 · A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial · 2015-03-12 · Original study
- AG-J03 · Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial · 2025-07-28 · Original study
22 DOI-eindeutige Arbeiten tragen 25 Quellen-IDs. Aliaspaare: AG-R02 = AG-S10; AG-R06 = AG-S08; AG-R07 = AG-S09. Diese Mehrfachverweise zählen nicht als zusätzliche Studien oder Replikationen.
Weiterdenken
