Altern/Studienübersicht - Versionsgeschichte

Glanz: Aging daily 6de7ad6c60c644adbcd2368820f28bd1 347a4110f8e6

2026-09-28T21:29:50Z

Aging daily 6de7ad6c60c644adbcd2368820f28bd1 347a4110f8e6

← Nächstältere Version		Version vom 28. September 2026, 23:29 Uhr
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	<div class="aging-research-world" lang="de" ~~style~~="~~max-width:1100px;margin:0 auto;line-height:1.65;overflow~~-~~wrap:anywhere;word-wrap:break-word;~~">		<div class="aging-research-world aging-journal" lang="de">
	<div class="~~aging~~-~~topbar~~"><span>[[Altern\|~~← Übersicht~~]]</span><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Studienübersicht\|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Study register\|🇬🇧]]</span></div></div>		<div class="aj-masthead"><div class="aj-brand"><span class="aj-monogram">[[Altern\|a.]]</span><span>[[Altern\|AGING]]<small>FORSCHUNG IM WANDEL</small></span></div><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Studienübersicht\|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Study register\|🇬🇧]]</span></div></div>
			<div class="aj-context"><strong>Fortlaufendes KI-Forschungsprojekt</strong>[[Altern/Über das Projekt\|Hintergründe · Ziele · Arbeitsweise]]<span>Stand 28.09.2026</span></div>
	== Ergänzung vom 28.09.2026 ==		<h1>Ergänzung vom 28.09.2026</h1>
			<div class="aj-deck">Literatur verbinden. Annahmen herausfordern. Funktion verstehen.</div>
			<div class="aj-article">

	=== AG-R01 ===		=== AG-R01 ===
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	[https://www.eneuro.org/content/10/6/ENEURO.0031-23.2023 Originalstudie]		[https://www.eneuro.org/content/10/6/ENEURO.0031-23.2023 Originalstudie]

			<div class="aj-return"><div class="aj-brand"><span class="aj-monogram">[[Altern\|a.]]</span><span>[[Altern\|AGING]]<small>FORSCHUNG IM WANDEL</small></span></div><span>[[Altern\|Zur Projektübersicht →]]</span></div>

	== Studienübersicht ==		== Studienübersicht ==
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	[[Altern/Forschungsberichte/2026-09-28\|Aktueller Bericht mit Quellen und Evidenz]] · [[Altern/Forschungsstatus\|Statusregeln]]		[[Altern/Forschungsberichte/2026-09-28\|Aktueller Bericht mit Quellen und Evidenz]] · [[Altern/Forschungsstatus\|Statusregeln]]

	----		== Neue menschliche Vergleichsmaßstäbe ==
	~~Forschungswelt Altern~~ / ~~Aging~~ · ~~Stand~~ 28.09.~~2026~~. Keine ~~Selbstmedikation~~ oder persönlichen Therapiepläne.
			[[Altern/Ansätze gegen Altern\|Vollständige Evidenzeinordnung und Quellen AG-J01 bis AG-J03]]

			* AG-J01 · Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial · 2014-05-27 · [https://jamanetwork.com/journals/jama/fullarticle/1875328 Original study]
			* AG-J02 · A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial · 2015-03-12 · [https://www.sciencedirect.com/science/article/pii/S0140673615604615 Original study]
			* AG-J03 · Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial · 2025-07-28 · [https://jamanetwork.com/journals/jama/fullarticle/2837046 Original study]

			22 DOI-eindeutige Arbeiten tragen 25 Quellen-IDs. Aliaspaare: AG-R02 = AG-S10; AG-R06 = AG-S08; AG-R07 = AG-S09. Diese Mehrfachverweise zählen nicht als zusätzliche Studien oder Replikationen.

			</div>
			<div class="aj-section-title"><h2>Weiterdenken</h2></div><div class="aj-tiles"><div class="aj-tile"><div class="aj-thumb">[[File:Bovine Pulmonary Artery Endothelial Cells Fluorescent Image.jpg\|120px\|frameless\|link=Altern/Ansätze gegen Altern\|alt=Fluoreszenzaufnahme boviner Endothelzellen mit markierten Zellkernen, Aktin und Mitochondrien.]]</div><div><div class="aj-tile-title">[[Altern/Ansätze gegen Altern\|Ansätze gegen Altern]]</div><div class="aj-tile-desc">Evidenz und Funktionsendpunkte</div></div></div><div class="aj-tile"><div class="aj-thumb aj-type-thumb">[[Altern/Erkenntniskette\|→]]</div><div><div class="aj-tile-title">[[Altern/Erkenntniskette\|Erkenntniskette]]</div><div class="aj-tile-desc">Wie Studien neue Fragen erzeugen</div></div></div><div class="aj-tile"><div class="aj-thumb">[[File:DNA double helix.svg\|120px\|frameless\|link=Altern/Forschungskolleg\|alt=Schematische Darstellung einer DNA-Doppelhelix.]]</div><div><div class="aj-tile-title">[[Altern/Forschungskolleg\|Forschungskolleg]]</div><div class="aj-tile-desc">16 Basisaufträge + 4 neue Vertiefungen</div></div></div></div>
			<div class="aj-footer"><div class="aj-brand"><span class="aj-monogram">[[Altern\|a.]]</span><span>[[Altern\|AGING]]<small>FORSCHUNG IM WANDEL</small></span></div><div class="aj-context">[[Altern\|Projektübersicht]][[Altern/Über das Projekt\|Ziele & Methoden]][[Altern/Erkenntniskette\|Erkenntniskette]]</div><div class="aj-meta">KI-gestützte Literaturarbeit und Modellbildung. Keine eigenen Labor- oder klinischen Studien. Keine persönlichen Therapiepläne.</div><div class="aj-credits">Bildnachweise · Illustrationen, keine Projektdaten: [https://commons.wikimedia.org/wiki/File:Axolotl_Portrait.jpg Axolotl] — LoKiLeCh ([https://creativecommons.org/licenses/by-sa/3.0/ CC BY-SA 3.0]) · [https://commons.wikimedia.org/wiki/File:XBio_illustration_%E2%80%93_Neuron.png Nervenzelle] — explorebiology (Explore Biology) ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0]) · [https://commons.wikimedia.org/wiki/File:DNA_double_helix.svg DNA] — Biochemlife ([https://creativecommons.org/licenses/by-sa/4.0/ CC BY-SA 4.0]) · [https://commons.wikimedia.org/wiki/File:Bovine_Pulmonary_Artery_Endothelial_Cells_Fluorescent_Image.jpg Bovine Endothelzellen] — Erin Rod ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0])</div></div>
	</div>		</div>
	[[Category:Altern / Aging]]		[[Category:Altern / Aging]]

Glanz: Aging daily d355518b4a7246438ba5f40ea2cf2a50 347a4110f8e6

2026-09-28T20:56:08Z

Aging daily d355518b4a7246438ba5f40ea2cf2a50 347a4110f8e6

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 <div class="aging-research-world" lang="de" style="max-width:1100px;margin:0 auto;line-height:1.65;overflow-wrap:anywhere;word-wrap:break-word;">
-[[Altern|← Übersicht]] · [[Aging/Study register|English]]
+<div class="aging-topbar"><span>[[Altern|← Übersicht]]</span><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Studienübersicht|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Study register|🇬🇧]]</span></div></div>
 == Studienübersicht ==

Glanz: Aging – freigegebene Erstveröffentlichung 6faa740d2c794e56888ab060b71d3212 347a4110f8e6

2026-09-28T20:06:12Z

Aging – freigegebene Erstveröffentlichung 6faa740d2c794e56888ab060b71d3212 347a4110f8e6

Neue Seite

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<div class="aging-research-world" lang="de" style="max-width:1100px;margin:0 auto;line-height:1.65;overflow-wrap:anywhere;word-wrap:break-word;">
[[Altern|← Übersicht]] · [[Aging/Study register|English]]

== Studienübersicht ==

DOI, Datum, Modell, Design, Evidenz und Peer-Review.

Publikationsdatum bezeichnet das erste Online-Datum, beim Preprint die ausgewiesene Fassung. Stärke bezieht sich auf den jeweiligen Aussagebereich; sämtliche Literaturbefunde sind ⚪ Projektstufe 1. „Nicht beurteilt“ ist keine Bestätigung und keine Widerlegung.

=== AG-S01 ===
'''Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration'''

Yu Q et al. · Developmental Cell · 2023-10-24 · DOI 10.1016/j.devcel.2023.09.009

Modell / Design: Axolotl limb; Gain/loss of function.

Evidenz: moderate, preclinical mechanism. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Primary abstract and article metadata.

[https://pubmed.ncbi.nlm.nih.gov/37879337/ Originalquelle]

=== AG-S02 ===
'''Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration'''

Wei X et al. · Science · 2022-09-02 · DOI 10.1126/science.abp9444

Modell / Design: Axolotl telencephalon; Spatial single-cell transcriptomics.

Evidenz: moderate, descriptive animal atlas. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Primary abstract and article metadata.

[https://doi.org/10.1126/science.abp9444 Originalquelle]

=== AG-S03 ===
'''Molecular basis of positional memory in limb regeneration'''

Otsuki L et al. · Nature · 2025-05-21 · DOI 10.1038/s41586-025-09036-5

Modell / Design: Axolotl limb; Lineage analysis and signalling perturbation.

Evidenz: moderate, preclinical mechanism. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text and primary abstract.

[https://www.nature.com/articles/s41586-025-09036-5 Originalquelle]

=== AG-S04 ===
'''Adrenergic signaling coordinates distant and local responses to amputation in axolotl'''

Payzin-Dogru D et al. · Cell · 2025-10-24 · DOI 10.1016/j.cell.2025.09.025

Modell / Design: Axolotl amputation; Systemic and local signalling perturbation.

Evidenz: moderate, preclinical mechanism. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher summary; PMC publication metadata.

[https://www.sciencedirect.com/science/article/pii/S0092867425011250 Originalquelle]

=== AG-S05 ===
'''Neuronal activation in the axolotl brain promotes tail regeneration'''

Walker SE et al. · npj Regenerative Medicine · 2025-05-08 · DOI 10.1038/s41536-025-00413-2

Modell / Design: Axolotl brain and tail; Neural mapping and pharmacological perturbation.

Evidenz: moderate, preclinical mechanism. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.

[https://www.nature.com/articles/s41536-025-00413-2 Originalquelle]

=== AG-S06 ===
'''Metabolic changes during cardiac regeneration in the axolotl'''

Dittrich A et al. · Developmental Dynamics · 2025-03-22 · DOI 10.1002/dvdy.70020

Modell / Design: Axolotl cardiac cryoinjury; Metabolic profiling and oxygen intervention.

Evidenz: limited-to-moderate, exploratory animal study. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher metadata and PMC indexed full text.

[https://anatomypubs.onlinelibrary.wiley.com/doi/abs/10.1002/dvdy.70020 Originalquelle]

=== AG-S07 ===
'''A characterization of axolotl digit regeneration: conserved mechanisms, divergent patterning, and a critical role for hedgehog signaling'''

Griffiths JR et al. · npj Regenerative Medicine · 2026-03-25 · DOI 10.1038/s41536-026-00461-2

Modell / Design: Juvenile axolotl digits; Anatomical comparison and hedgehog perturbation.

Evidenz: moderate, endpoint- and anatomy-specific animal evidence. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.

[https://www.nature.com/articles/s41536-026-00461-2 Originalquelle]

=== AG-S08 ===
'''Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains'''

Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y

Modell / Design: Mouse, killifish, human iPSC-derived neurons; Activity-based proteomics and perturbation.

Evidenz: moderate, multi-model preclinical mechanism. Begutachtet: ja.

Unabhängige Reproduktion: Multiple cohorts/models within one paper; external replication not assessed. Zugriff: Publisher full text.

[https://www.nature.com/articles/s41467-026-71921-y Originalquelle]

=== AG-S09 ===
'''Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment'''

Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z

Modell / Design: Mouse hippocampus and primary neurons; Viral/genetic manipulation and behavioural readouts.

Evidenz: moderate, preclinical intervention. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.

[https://www.nature.com/articles/s43587-025-00940-z Originalquelle]

=== AG-S10 ===
'''Ageing promotes microglial accumulation of slow-degrading synaptic proteins'''

Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9

Modell / Design: Mouse neuronal proteome; complementary human material; Cell-specific pulse-chase proteomics and microglial analysis.

Evidenz: moderate, descriptive/longitudinal protein-tracing animal evidence. Begutachtet: ja.

Unabhängige Reproduktion: not assessed. Zugriff: Publisher full text.

[https://www.nature.com/articles/s41586-025-09987-9 Originalquelle]

=== AG-S11 ===
'''Single-cell transcriptomic and genomic changes in the ageing human brain'''

Jeffries AM et al. · Nature · 2025-09-03 · DOI 10.1038/s41586-025-09435-8

Modell / Design: Human post-mortem prefrontal cortex; snRNA-seq, single-cell genome sequencing, spatial validation.

Evidenz: moderate, cross-sectional human observation. Begutachtet: ja.

Unabhängige Reproduktion: Within-paper orthogonal validation; external replication not assessed. Zugriff: Publisher full text.

[https://www.nature.com/articles/s41586-025-09435-8 Originalquelle]

=== AG-S12 ===
'''Organ-specific proteomic aging clocks predict disease and longevity across diverse populations'''

Wang Y et al. · Nature Aging · 2025-11-26 · DOI 10.1038/s43587-025-01016-8

Modell / Design: UK, Chinese and US human cohorts; Observational plasma proteomics with external cohort validation.

Evidenz: moderate-to-strong for prediction; not causal or interventional. Begutachtet: ja.

Unabhängige Reproduktion: External cohorts within one publication; distinct external team not established. Zugriff: Publisher full text.

[https://www.nature.com/articles/s43587-025-01016-8 Originalquelle]

=== AG-S13 ===
'''Shifts in protein aggregate stability define proteostasis decline in the aging human brain'''

Anderton E et al. · bioRxiv · 2026-04-18 · DOI 10.64898/2026.03.27.714902

Modell / Design: Human post-mortem hippocampus; Detergent-fractionation proteomics.

Evidenz: low, unreviewed human observation. Begutachtet: NEIN – Preprint.

Unabhängige Reproduktion: not established. Zugriff: Version-2 indexed abstract; version-1 primary full text; version-2 metadata.

[https://pubmed.ncbi.nlm.nih.gov/41959428/ Originalquelle]

=== AG-S14 ===
'''Temperature-Dependent Modulation of Cardiac Metabolism, Post-Injury Survival and Regenerative Rate in Axolotls'''

Dittrich A et al. · Metabolites · 2026-06-13 · DOI 10.3390/metabo16060414

Modell / Design: Adult axolotl cardiac cryoinjury; Temperature intervention; imaging, physiology and histology.

Evidenz: limited-to-moderate, small preclinical groups. Begutachtet: ja.

Unabhängige Reproduktion: Not assessed; author overlap with AG-S06. Zugriff: PMC primary full text and PubMed publication metadata.

[https://pmc.ncbi.nlm.nih.gov/articles/PMC13303739/ Originalquelle]

[[Altern/Forschungsberichte/2026-09-28|Aktueller Bericht mit Quellen und Evidenz]] · [[Altern/Forschungsstatus|Statusregeln]]

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Forschungswelt Altern / Aging · Stand 28.09.2026. Keine Selbstmedikation oder persönlichen Therapiepläne.
</div>
[[Category:Altern / Aging]]