Aging/Study register - Versionsgeschichte

Glanz: Aging daily b1de0c2b9a8f49a2a3542c500ab4bae3 d8eded416f0c

2026-09-28T21:30:02Z

Aging daily b1de0c2b9a8f49a2a3542c500ab4bae3 d8eded416f0c

← Nächstältere Version		Version vom 28. September 2026, 23:30 Uhr
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	<div class="aging-research-world" lang="en" ~~style~~="~~max-width:1100px;margin:0 auto;line-height:1.65;overflow~~-~~wrap:anywhere;word-wrap:break-word;~~">		<div class="aging-research-world aging-journal" lang="en">
	<div class="~~aging~~-~~topbar~~"><span>[[Aging\|~~← Overview~~]]</span><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Studienübersicht\|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Study register\|🇬🇧]]</span></div></div>		<div class="aj-masthead"><div class="aj-brand"><span class="aj-monogram">[[Aging\|a.]]</span><span>[[Aging\|AGING]]<small>RESEARCH IN PROGRESS</small></span></div><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Studienübersicht\|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Study register\|🇬🇧]]</span></div></div>
			<div class="aj-context"><strong>An evolving AI research project</strong>[[Aging/About the project\|Background · goals · methods]]<span>Updated 28 Sep 2026</span></div>
	== Addition dated 2026-09-28 ==		<h1>Addition dated 2026-09-28</h1>
			<div class="aj-deck">Connect the literature. Challenge assumptions. Understand function.</div>
			<div class="aj-article">

	=== AG-R01 ===		=== AG-R01 ===
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	[https://www.eneuro.org/content/10/6/ENEURO.0031-23.2023 Primary study]		[https://www.eneuro.org/content/10/6/ENEURO.0031-23.2023 Primary study]

			<div class="aj-return"><div class="aj-brand"><span class="aj-monogram">[[Aging\|a.]]</span><span>[[Aging\|AGING]]<small>RESEARCH IN PROGRESS</small></span></div><span>[[Aging\|Back to the project →]]</span></div>

	== Study register ==		== Study register ==
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	[[Aging/Research reports/2026-09-28\|Current report with sources and evidence]] · [[Aging/Research status\|Status rules]]		[[Aging/Research reports/2026-09-28\|Current report with sources and evidence]] · [[Aging/Research status\|Status rules]]

	----		== New human benchmarks ==
	~~Altern~~ / ~~Aging research world~~ · ~~Updated 2026~~-09-28. No ~~self-medication~~ or personal treatment plans.
			[[Aging/Approaches to aging\|Full evidence assessment and sources AG-J01 to AG-J03]]

			* AG-J01 · Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial · 2014-05-27 · [https://jamanetwork.com/journals/jama/fullarticle/1875328 Original study]
			* AG-J02 · A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial · 2015-03-12 · [https://www.sciencedirect.com/science/article/pii/S0140673615604615 Original study]
			* AG-J03 · Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial · 2025-07-28 · [https://jamanetwork.com/journals/jama/fullarticle/2837046 Original study]

			22 DOI-unique studies have 25 source IDs. Alias pairs: AG-R02 = AG-S10; AG-R06 = AG-S08; AG-R07 = AG-S09. These duplicate references do not count as additional studies or replications.

			</div>
			<div class="aj-section-title"><h2>Continue exploring</h2></div><div class="aj-tiles"><div class="aj-tile"><div class="aj-thumb">[[File:Bovine Pulmonary Artery Endothelial Cells Fluorescent Image.jpg\|120px\|frameless\|link=Aging/Approaches to aging\|alt=Fluorescence micrograph of bovine endothelial cells with labeled nuclei, actin and mitochondria.]]</div><div><div class="aj-tile-title">[[Aging/Approaches to aging\|Approaches to aging]]</div><div class="aj-tile-desc">Evidence and functional outcomes</div></div></div><div class="aj-tile"><div class="aj-thumb aj-type-thumb">[[Aging/Evidence chain\|→]]</div><div><div class="aj-tile-title">[[Aging/Evidence chain\|Evidence chain]]</div><div class="aj-tile-desc">How studies generate new questions</div></div></div><div class="aj-tile"><div class="aj-thumb">[[File:DNA double helix.svg\|120px\|frameless\|link=Aging/Research colloquium\|alt=Schematic illustration of a DNA double helix.]]</div><div><div class="aj-tile-title">[[Aging/Research colloquium\|Research colloquium]]</div><div class="aj-tile-desc">16 foundation assignments + 4 new deep dives</div></div></div></div>
			<div class="aj-footer"><div class="aj-brand"><span class="aj-monogram">[[Aging\|a.]]</span><span>[[Aging\|AGING]]<small>RESEARCH IN PROGRESS</small></span></div><div class="aj-context">[[Aging\|Project overview]][[Aging/About the project\|Goals & methods]][[Aging/Evidence chain\|Evidence chain]]</div><div class="aj-meta">AI-assisted literature research and model building. No laboratory or clinical studies conducted by this project. No personal treatment plans.</div><div class="aj-credits">Image credits · Illustrations, not project data: [https://commons.wikimedia.org/wiki/File:Axolotl_Portrait.jpg Axolotl] — LoKiLeCh ([https://creativecommons.org/licenses/by-sa/3.0/ CC BY-SA 3.0]) · [https://commons.wikimedia.org/wiki/File:XBio_illustration_%E2%80%93_Neuron.png Neuron] — explorebiology (Explore Biology) ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0]) · [https://commons.wikimedia.org/wiki/File:DNA_double_helix.svg DNA] — Biochemlife ([https://creativecommons.org/licenses/by-sa/4.0/ CC BY-SA 4.0]) · [https://commons.wikimedia.org/wiki/File:Bovine_Pulmonary_Artery_Endothelial_Cells_Fluorescent_Image.jpg Bovine endothelial cells] — Erin Rod ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0])</div></div>
	</div>		</div>
	[[Category:Altern / Aging]]		[[Category:Altern / Aging]]

Glanz: Aging daily b31948d7a2e04624b57f93971e4fa3ca d8eded416f0c

2026-09-28T20:56:12Z

Aging daily b31948d7a2e04624b57f93971e4fa3ca d8eded416f0c

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 <div class="aging-research-world" lang="en" style="max-width:1100px;margin:0 auto;line-height:1.65;overflow-wrap:anywhere;word-wrap:break-word;">
-[[Aging|← Overview]] · [[Altern/Studienübersicht|Deutsch]]
+<div class="aging-topbar"><span>[[Aging|← Overview]]</span><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Studienübersicht|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Study register|🇬🇧]]</span></div></div>
 == Study register ==

Glanz: Aging – freigegebene Erstveröffentlichung 6faa740d2c794e56888ab060b71d3212 d8eded416f0c

2026-09-28T20:06:14Z

Aging – freigegebene Erstveröffentlichung 6faa740d2c794e56888ab060b71d3212 d8eded416f0c

Neue Seite

__NOTOC__
<div class="aging-research-world" lang="en" style="max-width:1100px;margin:0 auto;line-height:1.65;overflow-wrap:anywhere;word-wrap:break-word;">
[[Aging|← Overview]] · [[Altern/Studienübersicht|Deutsch]]

== Study register ==

DOI, date, model, design, evidence and peer review.

Publication date means first online publication, or the stated preprint version. Strength refers to the specified claim scope; all literature findings are ⚪ project level 1. “Not assessed” means neither confirmation nor refutation.

=== AG-S01 ===
'''Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration'''

Yu Q et al. · Developmental Cell · 2023-10-24 · DOI 10.1016/j.devcel.2023.09.009

Model / design: Axolotl limb; Gain/loss of function.

Evidence: moderate, preclinical mechanism. Peer reviewed: yes.

Independent replication: not assessed. Access: Primary abstract and article metadata.

[https://pubmed.ncbi.nlm.nih.gov/37879337/ Original source]

=== AG-S02 ===
'''Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration'''

Wei X et al. · Science · 2022-09-02 · DOI 10.1126/science.abp9444

Model / design: Axolotl telencephalon; Spatial single-cell transcriptomics.

Evidence: moderate, descriptive animal atlas. Peer reviewed: yes.

Independent replication: not assessed. Access: Primary abstract and article metadata.

[https://doi.org/10.1126/science.abp9444 Original source]

=== AG-S03 ===
'''Molecular basis of positional memory in limb regeneration'''

Otsuki L et al. · Nature · 2025-05-21 · DOI 10.1038/s41586-025-09036-5

Model / design: Axolotl limb; Lineage analysis and signalling perturbation.

Evidence: moderate, preclinical mechanism. Peer reviewed: yes.

Independent replication: not assessed. Access: Publisher full text and primary abstract.

[https://www.nature.com/articles/s41586-025-09036-5 Original source]

=== AG-S04 ===
'''Adrenergic signaling coordinates distant and local responses to amputation in axolotl'''

Payzin-Dogru D et al. · Cell · 2025-10-24 · DOI 10.1016/j.cell.2025.09.025

Model / design: Axolotl amputation; Systemic and local signalling perturbation.

Evidence: moderate, preclinical mechanism. Peer reviewed: yes.

Independent replication: not assessed. Access: Publisher summary; PMC publication metadata.

[https://www.sciencedirect.com/science/article/pii/S0092867425011250 Original source]

=== AG-S05 ===
'''Neuronal activation in the axolotl brain promotes tail regeneration'''

Walker SE et al. · npj Regenerative Medicine · 2025-05-08 · DOI 10.1038/s41536-025-00413-2

Model / design: Axolotl brain and tail; Neural mapping and pharmacological perturbation.

Evidence: moderate, preclinical mechanism. Peer reviewed: yes.

Independent replication: not assessed. Access: Publisher full text.

[https://www.nature.com/articles/s41536-025-00413-2 Original source]

=== AG-S06 ===
'''Metabolic changes during cardiac regeneration in the axolotl'''

Dittrich A et al. · Developmental Dynamics · 2025-03-22 · DOI 10.1002/dvdy.70020

Model / design: Axolotl cardiac cryoinjury; Metabolic profiling and oxygen intervention.

Evidence: limited-to-moderate, exploratory animal study. Peer reviewed: yes.

Independent replication: not assessed. Access: Publisher metadata and PMC indexed full text.

[https://anatomypubs.onlinelibrary.wiley.com/doi/abs/10.1002/dvdy.70020 Original source]

=== AG-S07 ===
'''A characterization of axolotl digit regeneration: conserved mechanisms, divergent patterning, and a critical role for hedgehog signaling'''

Griffiths JR et al. · npj Regenerative Medicine · 2026-03-25 · DOI 10.1038/s41536-026-00461-2

Model / design: Juvenile axolotl digits; Anatomical comparison and hedgehog perturbation.

Evidence: moderate, endpoint- and anatomy-specific animal evidence. Peer reviewed: yes.

Independent replication: not assessed. Access: Publisher full text.

[https://www.nature.com/articles/s41536-026-00461-2 Original source]

=== AG-S08 ===
'''Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains'''

Sahu AK et al. · Nature Communications · 2026-04-21 · DOI 10.1038/s41467-026-71921-y

Model / design: Mouse, killifish, human iPSC-derived neurons; Activity-based proteomics and perturbation.

Evidence: moderate, multi-model preclinical mechanism. Peer reviewed: yes.

Independent replication: Multiple cohorts/models within one paper; external replication not assessed. Access: Publisher full text.

[https://www.nature.com/articles/s41467-026-71921-y Original source]

=== AG-S09 ===
'''Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment'''

Remesal L et al. · Nature Aging · 2025-08-19 · DOI 10.1038/s43587-025-00940-z

Model / design: Mouse hippocampus and primary neurons; Viral/genetic manipulation and behavioural readouts.

Evidence: moderate, preclinical intervention. Peer reviewed: yes.

Independent replication: not assessed. Access: Publisher full text.

[https://www.nature.com/articles/s43587-025-00940-z Original source]

=== AG-S10 ===
'''Ageing promotes microglial accumulation of slow-degrading synaptic proteins'''

Guldner IH et al. · Nature · 2026-01-21 · DOI 10.1038/s41586-025-09987-9

Model / design: Mouse neuronal proteome; complementary human material; Cell-specific pulse-chase proteomics and microglial analysis.

Evidence: moderate, descriptive/longitudinal protein-tracing animal evidence. Peer reviewed: yes.

Independent replication: not assessed. Access: Publisher full text.

[https://www.nature.com/articles/s41586-025-09987-9 Original source]

=== AG-S11 ===
'''Single-cell transcriptomic and genomic changes in the ageing human brain'''

Jeffries AM et al. · Nature · 2025-09-03 · DOI 10.1038/s41586-025-09435-8

Model / design: Human post-mortem prefrontal cortex; snRNA-seq, single-cell genome sequencing, spatial validation.

Evidence: moderate, cross-sectional human observation. Peer reviewed: yes.

Independent replication: Within-paper orthogonal validation; external replication not assessed. Access: Publisher full text.

[https://www.nature.com/articles/s41586-025-09435-8 Original source]

=== AG-S12 ===
'''Organ-specific proteomic aging clocks predict disease and longevity across diverse populations'''

Wang Y et al. · Nature Aging · 2025-11-26 · DOI 10.1038/s43587-025-01016-8

Model / design: UK, Chinese and US human cohorts; Observational plasma proteomics with external cohort validation.

Evidence: moderate-to-strong for prediction; not causal or interventional. Peer reviewed: yes.

Independent replication: External cohorts within one publication; distinct external team not established. Access: Publisher full text.

[https://www.nature.com/articles/s43587-025-01016-8 Original source]

=== AG-S13 ===
'''Shifts in protein aggregate stability define proteostasis decline in the aging human brain'''

Anderton E et al. · bioRxiv · 2026-04-18 · DOI 10.64898/2026.03.27.714902

Model / design: Human post-mortem hippocampus; Detergent-fractionation proteomics.

Evidence: low, unreviewed human observation. Peer reviewed: NO – preprint.

Independent replication: not established. Access: Version-2 indexed abstract; version-1 primary full text; version-2 metadata.

[https://pubmed.ncbi.nlm.nih.gov/41959428/ Original source]

=== AG-S14 ===
'''Temperature-Dependent Modulation of Cardiac Metabolism, Post-Injury Survival and Regenerative Rate in Axolotls'''

Dittrich A et al. · Metabolites · 2026-06-13 · DOI 10.3390/metabo16060414

Model / design: Adult axolotl cardiac cryoinjury; Temperature intervention; imaging, physiology and histology.

Evidence: limited-to-moderate, small preclinical groups. Peer reviewed: yes.

Independent replication: Not assessed; author overlap with AG-S06. Access: PMC primary full text and PubMed publication metadata.

[https://pmc.ncbi.nlm.nih.gov/articles/PMC13303739/ Original source]

[[Aging/Research reports/2026-09-28|Current report with sources and evidence]] · [[Aging/Research status|Status rules]]

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Altern / Aging research world · Updated 2026-09-28. No self-medication or personal treatment plans.
</div>
[[Category:Altern / Aging]]