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Aging/Mechanisms of aging - Versionsgeschichte
2026-09-29T02:38:49Z
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Glanz: Aging daily 286609ebd48d4bca9de61efeae9935d4 4249dcd4fb6d
2026-09-28T21:29:54Z
<p>Aging daily 286609ebd48d4bca9de61efeae9935d4 4249dcd4fb6d</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Version vom 28. September 2026, 23:29 Uhr</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><<del style="font-weight: bold; text-decoration: none;">div </del>class="<del style="font-weight: bold; text-decoration: none;">aging</del>-<del style="font-weight: bold; text-decoration: none;">topbar</del>"><span>[[Aging|<del style="font-weight: bold; text-decoration: none;">← Overview</del>]]</span><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Mechanismen des Alterns|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Mechanisms of aging|🇬🇧]]</span></div></div></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><div class</ins>="<ins style="font-weight: bold; text-decoration: none;">aj</ins>-<ins style="font-weight: bold; text-decoration: none;">masthead"><div class="aj</ins>-<ins style="font-weight: bold; text-decoration: none;">brand</ins>"><<ins style="font-weight: bold; text-decoration: none;">span </ins>class="<ins style="font-weight: bold; text-decoration: none;">aj</ins>-<ins style="font-weight: bold; text-decoration: none;">monogram</ins>"<ins style="font-weight: bold; text-decoration: none;">>[[Aging|a.]]</span</ins>><span>[[Aging|<ins style="font-weight: bold; text-decoration: none;">AGING</ins>]]<ins style="font-weight: bold; text-decoration: none;"><small>RESEARCH IN PROGRESS</small></ins></span<ins style="font-weight: bold; text-decoration: none;">></div</ins>><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Mechanismen des Alterns|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Mechanisms of aging|🇬🇧]]</span></div></div></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><div class="aj-context"><strong>An evolving AI research project</strong>[[Aging/About the project|Background · goals · methods]]<span>Updated 28 Sep 2026</span></div></ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== </del>Mechanisms of aging ==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><h1></ins>Mechanisms of aging<ins style="font-weight: bold; text-decoration: none;"></h1></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><div class</ins>=<ins style="font-weight: bold; text-decoration: none;">"aj-deck">Connect the literature. Challenge assumptions. Understand function.</div></ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Separate causal mechanisms from measurable markers.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Separate causal mechanisms from measurable markers.</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>----</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></div></ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Altern </del>/ Aging <del style="font-weight: bold; text-decoration: none;">research world · Updated 2026</del>-<del style="font-weight: bold; text-decoration: none;">09</del>-<del style="font-weight: bold; text-decoration: none;">28</del>. No <del style="font-weight: bold; text-decoration: none;">self-medication </del>or personal treatment plans.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><div class="aj-section-title"><h2>Continue exploring</h2></div><div class="aj-tiles"><div class="aj-tile"><div class="aj-thumb">[[File:Bovine Pulmonary Artery Endothelial Cells Fluorescent Image.jpg|120px|frameless|link=Aging/Approaches to aging|alt=Fluorescence micrograph of bovine endothelial cells with labeled nuclei, actin and mitochondria.]]</div><div><div class="aj-tile-title">[[Aging/Approaches to aging|Approaches to aging]]</div><div class="aj-tile-desc">Evidence and functional outcomes</div></div></div><div class="aj-tile"><div class="aj-thumb aj-type-thumb">[[Aging/Evidence chain|→]]</div><div><div class="aj-tile-title">[[Aging/Evidence chain|Evidence chain]]</div><div class="aj-tile-desc">How studies generate new questions</div></div></div><div class="aj</ins>-<ins style="font-weight: bold; text-decoration: none;">tile"><div class="aj</ins>-<ins style="font-weight: bold; text-decoration: none;">thumb">[[File:DNA double helix.svg|120px|frameless|link=Aging/Research colloquium|alt=Schematic illustration of a DNA double helix.]]</div><div><div class="aj</ins>-<ins style="font-weight: bold; text-decoration: none;">tile</ins>-<ins style="font-weight: bold; text-decoration: none;">title">[[Aging/Research colloquium|Research colloquium]]</div><div class="aj-tile-desc">16 foundation assignments + 4 new deep dives</div></div></div></div></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><div class="aj-footer"><div class="aj-brand"><span class="aj-monogram">[[Aging|a.]]</span><span>[[Aging|AGING]]<small>RESEARCH IN PROGRESS</small><</ins>/<ins style="font-weight: bold; text-decoration: none;">span></div><div class="aj-context">[[</ins>Aging<ins style="font-weight: bold; text-decoration: none;">|Project overview]][[Aging/About the project|Goals & methods]][[Aging/Evidence chain|Evidence chain]]</div><div class="aj</ins>-<ins style="font-weight: bold; text-decoration: none;">meta">AI</ins>-<ins style="font-weight: bold; text-decoration: none;">assisted literature research and model building</ins>. No <ins style="font-weight: bold; text-decoration: none;">laboratory </ins>or <ins style="font-weight: bold; text-decoration: none;">clinical studies conducted by this project. No </ins>personal treatment plans.<ins style="font-weight: bold; text-decoration: none;"></div><div class="aj-credits">Image credits · Illustrations, not project data: [https://commons.wikimedia.org/wiki/File:Axolotl_Portrait.jpg Axolotl] — LoKiLeCh ([https://creativecommons.org/licenses/by-sa/3.0/ CC BY-SA 3.0]) · [https://commons.wikimedia.org/wiki/File:XBio_illustration_%E2%80%93_Neuron.png Neuron] — explorebiology (Explore Biology) ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0]) · [https://commons.wikimedia.org/wiki/File:DNA_double_helix.svg DNA] — Biochemlife ([https://creativecommons.org/licenses/by-sa/4.0/ CC BY-SA 4.0]) · [https://commons.wikimedia.org/wiki/File:Bovine_Pulmonary_Artery_Endothelial_Cells_Fluorescent_Image.jpg Bovine endothelial cells] — Erin Rod ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0])</div></div></ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Altern / Aging]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Altern / Aging]]</div></td></tr>
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Glanz: Aging daily 9d3dc6b6ab424facafd8602ef0da0575 4249dcd4fb6d
2026-09-28T20:56:11Z
<p>Aging daily 9d3dc6b6ab424facafd8602ef0da0575 4249dcd4fb6d</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Version vom 28. September 2026, 22:56 Uhr</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Aging|← Overview]] <del style="font-weight: bold; text-decoration: none;">· </del>[[Altern/Mechanismen des Alterns|<del style="font-weight: bold; text-decoration: none;">Deutsch</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><div class="aging-topbar"><span></ins>[[Aging|← Overview]]<ins style="font-weight: bold; text-decoration: none;"></span><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch"></ins>[[Altern/Mechanismen des Alterns|<ins style="font-weight: bold; text-decoration: none;">🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Mechanisms of aging|🇬🇧</ins>]]<ins style="font-weight: bold; text-decoration: none;"></span></div></div></ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Mechanisms of aging ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Mechanisms of aging ==</div></td></tr>
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Glanz: Aging – freigegebene Erstveröffentlichung 6faa740d2c794e56888ab060b71d3212 4249dcd4fb6d
2026-09-28T20:06:14Z
<p>Aging – freigegebene Erstveröffentlichung 6faa740d2c794e56888ab060b71d3212 4249dcd4fb6d</p>
<p><b>Neue Seite</b></p><div>__NOTOC__<br />
<div class="aging-research-world" lang="en" style="max-width:1100px;margin:0 auto;line-height:1.65;overflow-wrap:anywhere;word-wrap:break-word;"><br />
[[Aging|← Overview]] · [[Altern/Mechanismen des Alterns|Deutsch]]<br />
<br />
== Mechanisms of aging ==<br />
<br />
Separate causal mechanisms from measurable markers.<br />
<br />
A mechanism must explain more than a correlation with chronological age. Build separate causal models for senescence, proteostasis, metabolism, inflammation and tissue organisation.<br />
<br />
Research task: specify necessary and sufficient conditions for each candidate. Name at least one finding that would falsify the model. Treat structural repair, functional recovery and changes in a biological clock as distinct endpoints.<br />
<br />
Methodological starting points: [https://pubmed.ncbi.nlm.nih.gov/37879337/ AG-S01] · [https://www.nature.com/articles/s41467-026-71921-y AG-S08] · [https://www.nature.com/articles/s43587-025-01016-8 AG-S12]<br />
<br />
[[Aging/Research reports/2026-09-28|Current report with sources and evidence]] · [[Aging/Research status|Status rules]]<br />
<br />
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Altern / Aging research world · Updated 2026-09-28. No self-medication or personal treatment plans.<br />
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[[Category:Altern / Aging]]</div>
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