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<p><b>Neue Seite</b></p><div>__NOTOC__<br />
<div class="aging-research-world aging-journal" lang="en"><br />
<div class="aj-masthead"><div class="aj-brand"><span class="aj-monogram">[[Aging|a.]]</span><span>[[Aging|AGING]]<small>RESEARCH IN PROGRESS</small></span></div><div class="aging-languages" role="navigation" aria-label="Sprache / Language"><span class="aging-language" title="Deutsch">[[Altern/Ansätze gegen Altern|🇩🇪]]</span><span class="aging-language" title="English">[[Aging/Approaches to aging|🇬🇧]]</span></div></div><br />
<div class="aj-context"><strong>An evolving AI research project</strong>[[Aging/About the project|Background · goals · methods]]<span>Updated 28 Sep 2026</span></div><br />
<h1>Approaches to aging</h1><br />
<div class="aj-article"><br />
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'''What may counter age-related functional decline''' · Updated 28 September 2026<br />
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This list grows with the evidence. Its first entries concern human function; subsequent entries are mechanistic candidates or untested hypotheses. Inclusion does not establish slowing of human aging. The order is not a personal treatment recommendation.<br />
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== AG-A01 · Structured physical activity ==<br />
'''Human function · Project level 1'''<br />
<br />
* '''Outcome / target:''' Less major mobility disability than with health education.<br />
* '''Population / model:''' Older adults at mobility risk.<br />
* '''Evidence:''' Randomised; functional endpoint.<br />
* '''Limits / counterevidence:''' Serious harms not excluded; no general aging reversal.<br />
* '''Next desk check:''' Check adherence, safety and separate long-term replications.<br />
* Sources: [https://jamanetwork.com/journals/jama/fullarticle/1875328 AG-J01 · 2014-05-27]<br />
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== AG-A02 · Combined programs for cognition ==<br />
'''Human function · Project level 1'''<br />
<br />
* '''Outcome / target:''' Small composite-test advantages over each study’s comparator.<br />
* '''Population / model:''' People at elevated cognitive risk.<br />
* '''Evidence:''' Two randomised cohorts; related programs.<br />
* '''Limits / counterevidence:''' Components unresolved; dementia prevention unproven. Assess burdens.<br />
* '''Next desk check:''' Check contact time, practice effects, daily relevance and counterstudies.<br />
* Sources: [https://www.sciencedirect.com/science/article/pii/S0140673615604615 AG-J02 · 2015-03-12]; [https://jamanetwork.com/journals/jama/fullarticle/2837046 AG-J03 · 2025-07-28]<br />
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== AG-A03 · TIMP2 as a functional candidate ==<br />
'''Preclinical · Project level 1'''<br />
<br />
* '''Outcome / target:''' Target: plasticity with preserved connections.<br />
* '''Population / model:''' Mouse.<br />
* '''Evidence:''' Preclinical; mechanism unresolved.<br />
* '''Limits / counterevidence:''' Direct neuronal action competes with microglial mediation.<br />
* '''Next desk check:''' Examine discrepancies and availability of comparative data.<br />
* Sources: [https://www.nature.com/articles/s41467-026-74906-z AG-R01 · 2026-08-12]; [https://www.nature.com/articles/nature22067 AG-R05 · 2017-04-19]; [https://www.eneuro.org/content/10/6/ENEURO.0031-23.2023 AG-R08 · 2023-06-15]<br />
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== AG-A04 · Targeted FTL1 regulation ==<br />
'''Preclinical · Project level 1'''<br />
<br />
* '''Outcome / target:''' Target: reliable neuronal function.<br />
* '''Population / model:''' Mouse.<br />
* '''Evidence:''' Mechanistic candidate.<br />
* '''Limits / counterevidence:''' Avoid blanket iron suppression; transferability unresolved.<br />
* '''Next desk check:''' Check cellular specificity, exposure and separate functional replication.<br />
* Sources: [https://www.nature.com/articles/s43587-025-00940-z AG-S09 · 2025-08-19]<br />
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== AG-A05 · Redox-dependent protein control ==<br />
'''Preclinical · Project level 1'''<br />
<br />
* '''Outcome / target:''' Target: function after selective DUB modulation.<br />
* '''Population / model:''' Vertebrate models.<br />
* '''Evidence:''' Mechanistic candidate.<br />
* '''Limits / counterevidence:''' Enzyme activity does not establish cognition; broad interventions ambiguous.<br />
* '''Next desk check:''' Seek selective mediation and functional counterevidence.<br />
* Sources: [https://www.nature.com/articles/s41467-026-71921-y AG-S08 · 2026-04-21]<br />
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== AG-A06 · Mitochondrial quality control ==<br />
'''Preclinical · Project level 1'''<br />
<br />
* '''Outcome / target:''' Target: actual restoration beyond favourable markers.<br />
* '''Population / model:''' Mouse.<br />
* '''Evidence:''' Limited; functional findings differ.<br />
* '''Limits / counterevidence:''' Do not equate prevention with reversal.<br />
* '''Next desk check:''' Prioritise age- and strain-matched comparisons.<br />
* Sources: [https://www.nature.com/articles/s41514-026-00351-3 AG-R03 · 2026-03-05]<br />
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== AG-A07 · Spatial control of regeneration ==<br />
'''Preclinical · Project level 1'''<br />
<br />
* '''Outcome / target:''' Target: correct reconnection following repair.<br />
* '''Population / model:''' Axolotl; injury.<br />
* '''Evidence:''' Comparative regeneration biology.<br />
* '''Limits / counterevidence:''' Tissue regrowth does not establish human aging benefit.<br />
* '''Next desk check:''' Check conserved mechanisms and transfer limits.<br />
* Sources: [https://www.nature.com/articles/s41586-025-09036-5 AG-S03 · 2025-05-21]<br />
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== AG-A08 · Understand senescence over time ==<br />
'''Preclinical · Project level 1'''<br />
<br />
* '''Outcome / target:''' Target: repair without chronic functional harm.<br />
* '''Population / model:''' Axolotl; regeneration.<br />
* '''Evidence:''' Context-dependent mechanistic candidate.<br />
* '''Limits / counterevidence:''' No basis for indiscriminate cell removal.<br />
* '''Next desk check:''' Compare timing, cell type and state resolution.<br />
* Sources: [https://pubmed.ncbi.nlm.nih.gov/37879337/ AG-S01 · 2023-10-24]<br />
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== AG-A09 · AG-T01: selective cargo degradation ==<br />
'''Hypothesis · Project level 2'''<br />
<br />
* '''Outcome / target:''' Hypothesis: jointly improve degradation, synapse preservation and function.<br />
* '''Population / model:''' Proposed aged neuronal system.<br />
* '''Evidence:''' Untested project synthesis.<br />
* '''Limits / counterevidence:''' Partial mediation and cargo selectivity unconfirmed.<br />
* '''Next desk check:''' Develop preregistrable balance measurements and alternative models.<br />
* Sources: [https://www.nature.com/articles/s41467-026-74906-z AG-R01 · 2026-08-12]; [https://www.nature.com/articles/s41586-025-09987-9 AG-R02 · 2026-01-21]; [https://www.eneuro.org/content/10/6/ENEURO.0031-23.2023 AG-R08 · 2023-06-15]<br />
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== AG-A10 · AG-H02: FTL1–redox–DUB ==<br />
'''Hypothesis · Project level 2'''<br />
<br />
* '''Outcome / target:''' Hypothesis: a causal mediation chain.<br />
* '''Population / model:''' No joint test.<br />
* '''Evidence:''' Low priority; untested.<br />
* '''Limits / counterevidence:''' Separate findings do not establish the chain.<br />
* '''Next desk check:''' First check direct prior evidence and counterevidence.<br />
* Sources: [https://www.nature.com/articles/s41467-026-71921-y AG-S08 · 2026-04-21]; [https://www.nature.com/articles/s43587-025-00940-z AG-S09 · 2025-08-19]<br />
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'''Updating:''' New approaches require a verifiable source or explicit hypothesis basis, a functional target endpoint, model limits and the next decisive countercheck. Failed or narrowed approaches remain visible with reasons. Category, evidence and project level are updated separately.<br />
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</div><br />
<div class="aj-section-title"><h2>Continue exploring</h2></div><div class="aj-tiles"><div class="aj-tile"><div class="aj-thumb aj-type-thumb">[[Aging/Evidence chain|→]]</div><div><div class="aj-tile-title">[[Aging/Evidence chain|Evidence chain]]</div><div class="aj-tile-desc">How studies generate new questions</div></div></div><div class="aj-tile"><div class="aj-thumb">[[File:DNA double helix.svg|120px|frameless|link=Aging/Research colloquium|alt=Schematic illustration of a DNA double helix.]]</div><div><div class="aj-tile-title">[[Aging/Research colloquium|Research colloquium]]</div><div class="aj-tile-desc">16 foundation assignments + 4 new deep dives</div></div></div></div><br />
<div class="aj-footer"><div class="aj-brand"><span class="aj-monogram">[[Aging|a.]]</span><span>[[Aging|AGING]]<small>RESEARCH IN PROGRESS</small></span></div><div class="aj-context">[[Aging|Project overview]][[Aging/About the project|Goals & methods]][[Aging/Evidence chain|Evidence chain]]</div><div class="aj-meta">AI-assisted literature research and model building. No laboratory or clinical studies conducted by this project. No personal treatment plans.</div><div class="aj-credits">Image credits · Illustrations, not project data: [https://commons.wikimedia.org/wiki/File:Axolotl_Portrait.jpg Axolotl] — LoKiLeCh ([https://creativecommons.org/licenses/by-sa/3.0/ CC BY-SA 3.0]) · [https://commons.wikimedia.org/wiki/File:XBio_illustration_%E2%80%93_Neuron.png Neuron] — explorebiology (Explore Biology) ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0]) · [https://commons.wikimedia.org/wiki/File:DNA_double_helix.svg DNA] — Biochemlife ([https://creativecommons.org/licenses/by-sa/4.0/ CC BY-SA 4.0]) · [https://commons.wikimedia.org/wiki/File:Bovine_Pulmonary_Artery_Endothelial_Cells_Fluorescent_Image.jpg Bovine endothelial cells] — Erin Rod ([https://creativecommons.org/licenses/by/4.0/ CC BY 4.0])</div></div><br />
</div><br />
[[Category:Altern / Aging]]</div>
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